Nargis Khan
Positions
Assistant Professor
Cumming School of Medicine
Full Member
The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases
Assistant Professor
Cumming School of Medicine
Contact information
Phone number
office: 403-220-8859
Background
Biography
Dr. Khan completed her Ph.D. at Jawahar Lal Nehru University, New Delhi, India, in studying infectious diseases. She then joined McGill University in Montreal, Canada as a postdoctoral fellow, where her research focused on understanding the host defence mechanism against respiratory pathogens. In 2022, she joined the Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine at the University of Calgary. She is an Assistant Professor and Canada Research Chair in Tuberculosis and other Respiratory Pathogens and a member of the Snyder Institute for Chronic Diseases. Her research program focuses on three conceptual frameworks of host defence: Host resistance, Disease tolerance and Trained immunity in inflammatory and chronic diseases.
Research
Areas of Research
Participation in university strategic initiatives
Awards
- Canada Research Chair in Tuberculosis and other Respiratory Pathogens, CIHR. 2023
- John R Evans Leaders Fund, Canadian Foundations for Innovation JELF. 2023
- CFI BRIF CL3 Upgrade Competition , Canadian Foundations for Innovation. 2022
- VPR Catalyst Grant, University of Calgary. 2022
Publications
- Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE. Erwan Pernet, Sarah Sun, Nicole Sarden, Saideep Gona, Angela Nguyen, Nargis Khan, Martin Mawhinney, Kim A Tran, Julia Chronopoulos, Dnyandeo Amberkar, Mina Sadeghi, Alexandre Grant, Shradha Wali, Renaud Prevel, Jun Ding, James G Martin, Ajitha Thanabalasuriar, Bryan G Yipp, Luis B Barreiro, Maziar Divangahi. Nature. (2023)
- Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection. Laura E Mendonca*, Erwan Pernet*, Nargis Khan*, Joaquin Sanz, Eva Kaufmann, Jeffrey Downey, Alexandre Grant, Marianna Orlova, Erwin Schurr, Connie Krawczyk, Russell G Jones, Luis B Barreiro, Maziar Divangahi * Equal contribution. Frontiers in Immunology. (2023)
- Brain motor and fear circuits regulate leukocytes during acute stress. Wolfram C Poller, Jeffrey Downey, Agnes A Mooslechner, Nargis Khan, Long Li, Christopher T Chan, Cameron S McAlpine, Chunliang Xu, Florian Kahles, Shun He, Henrike Janssen, John E Mindur, Sumnima Singh, Máté G Kiss, Laura Alonso-Herranz, Yoshiko Iwamoto, Rainer H Kohler, Lai Ping Wong, Kashish Chetal, Scott J Russo, Ruslan I Sadreyev, Ralph Weissleder, Matthias Nahrendorf, Paul S Frenette, Maziar Divangahi, Filip K Swirski. Nature. (2022)
- BCG vaccination provides protection against IAV but not SARS-CoV-2. Eva Kaufmann*, Nargis Khan*, Kim A Tran, Antigona Ulndreaj, Erwan Pernet, Ghislaine Fontes, Andréanne Lupien, Patrice Desmeules, Fiona McIntosh, Amina Abow, Simone JCFM Moorlag, Priya Debisarun, Karen Mossman, Arinjay Banerjee, Danielle Karo-Atar, Mina Sadeghi, Samira Mubareka, Donald C Vinh, Irah L King, Clinton S Robbins, Marcel A Behr, Mihai G Netea, Philippe Joubert, Maziar Divangahi *Equal Contribution. Cell Reports. (2022)
- M. tuberculosis reprograms hematopoietic stem cells to limit myelopoiesis and impair trained immunity. Nargis Khan, Jeffrey Downey, Joaquin Sanz, Eva Kaufmann, Birte Blankenhaus, Alain Pacis, Erwan Pernet, Eisha Ahmed, Silvia Cardoso, Anastasia Nijnik, Bruce Mazer, Christopher Sassetti, Marcel A Behr, Miguel P Soares, Luis B Barreiro, Maziar Divangahi. Cell. (2020)
- Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Maziar Divangahi, Peter Aaby, Shabaana Abdul Khader, Luis B Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R DiNardo, Jorge Dominguez-Andres, Raphael Duivenvoorden, Stephanie Fanucchi, Zahi Fayad, Elaine Fuchs, Melanie Hamon, Kate L Jeffrey, Nargis Khan, Leo AB Joosten, Eva Kaufmann, Eicke Latz, Giuseppe Matarese, Jos WM van der Meer, Musa Mhlanga, Simone JCFM Moorlag, Willem JM Mulder, Shruti Naik, Boris Novakovic, Luke O’Neill, Jordi Ochando, Keiko Ozato, Niels P Riksen, Robert Sauerwein, Edward R Sherwood, Andreas Schlitzer, Joachim L Schultze, Michael H Sieweke, Christine Stabell Benn, Henk Stunnenberg, Joseph Sun, Frank L van de Veerdonk, Sebastian Weis, David L Williams, Ramnik Xavier, Mihai G Netea. Nature Immunology. (2021)
- Novel approaches to preventing phagosomal infections: timing is key. Nathan C Peters, Nargis Khan, Christopher H Mody. Trends in Immunology. (2022)
- Intestinal dysbiosis compromises alveolar macrophage immunity to Mycobacterium tuberculosis. Nargis Khan, Laura Mendonca, Achal Dhariwal, Ghislaine Fontes, Dick Menzies, Jianguo Xia, Maziar Divangahi , Irah L King. Mucosal Immunology. (2019)
- β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1. Simone J C F M Moorlag, Nargis Khan, Boris Novakovic, Eva Kaufmann, Trees Jansen, Reinout van Crevel, Maziar Divangahi, Mihai G Netea. (2020)
- BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis.. Kaufmann E, Sanz J, Dunn JL, Khan N, Mendonça LE, Pacis A, Tzelepis F, Pernet E, Dumaine A, Grenier JC, Mailhot-Léonard F, Ahmed E, Belle J, Besla R, Mazer B, King IL, Nijnik A, Robbins CS, Barreiro LB, Divangahi M.. Cell. (2018)
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