Wallace MacNaughton

Dr. Wallace Keith MacNaughton, PhD, Professor Emeritus



Cumming School of Medicine, Department of Physiology and Pharmacology

Full Member

The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases

Child Health & Wellness Researcher

Alberta Children's Hospital Research Institute

Full Member

Inflammation Research Network


Gastrointestinal Research Group

Contact information

Web presence


Educational Background

PhD Physiology, Queen's University, 1989

MSc Biological Sciences, Queen's University, 1986

BSc Biological Sciences, Queen's University, 1984


Areas of Research

Tissue Regeneration

Inflammatory diseases of the gastrointestinal tract are associated with a variety of symptoms including pain, diarrhea, and malabsorption among others. Mucosal healing is considered the gold standard for efficacy of treatment.  We are investigating various aspects of mucosal healing, concentrating on the role of the epithelium in the resolution of the intestinal inflammatory response.  Our specific interest is in Activities  We are assessing role of activation of protease-activated receptor (PAR) 2, as well as novel bioactive peptides that are produced by proteases in the inflammatory milieu.  Other projects are looking at how certain dietary fibres may play a role in mucosal healing during inflammation, such as that which characterizes the inflammatory bowel diseases, Crohn's disease and ulcerative colitis.  Dr. MacNaughton is also involved in developing new organoid-based systems to study intestinal disease.  He is co-director of the Human Organoid Innovation Hub in the Snyder Institute for Chronic Diseases.

Participation in university strategic initiatives