Dr. T. Wayne Mattews

Dr. T. Wayne Matthews, MD, FRCS


Associate Professor - Medicine

Cumming School of Medicine, Department of Surgery


Arnie Charbonneau Cancer Institute

Contact information

Phone number

Office: 403.944.4501


Office: ENT Clinic, 1820 Richmond Road SW, Calgary, Alberta T2T 5C7

For media enquiries, contact

Kelly Johnston
Senior Communications Specialist

Please submit your media request here


Administrative Assistant

Kim Osborne
Email: kim.osborne@ahs.ca

Telephone: 403.944.4501



I am an Otolaryngologist – Head and Neck Surgery (FRCS, University of Ottawa) with advanced training in Head and Neck Oncologic and Reconstructive Surgery (University of Toronto). During my 12 years at Western University I was Residency Program Director. I have been an Assoc. Prof. at the University of Calgary since 2003. My roles included initiating the UofC Otolaryngology – Head and neck Surgery resident training program, being the first Program Director, serving as the Section Chief of Otolaryngology (2008 – 2018), Vice-Chair of the RCPS Oto-HNS Specialty Committee (2008 – 2014) and Chair (2014 – 2021). I am currently the President of the AMA Section of Oto-HNS (2021 – 2023) and the acting Executive Director of the Ohlson Research Initiative.


Areas of Research

Area of Focus
  • Functional Outcomes following treatment for Head and Neck Cancer
Summary of Research

Research interests are related to head and neck cancer. Specifically, I have focused on functional outcomes following treatment for H&N cancer, clinical pathways for H&N surgery, application of the Enhanced Recovery after Surgery (ERAS) process to head and neck surgery, and prognostic markers and individualized treatment in H&N cancer. I am an active collaborator in multi-centre studies through the national Collaborative Research Initiative (H&N Cancer).


Dautremont JF, Rudmik LR, Nakoneshny SC, Chandarana SP, Matthews TW, Schrag C, Fick GH, Dort JC. Understanding the impact of a clinical care pathway for major head and neck cancer resection on postdischarge healthcare utilization. Head Neck. 2015 Sep 18. doi: 10.1002/hed.24196. [Epub ahead of print] PubMed PMID: 26382252.

Dang M, Lysack JT, Wu T, Matthews TW, Chandarana SP, Brockton NT, Bose P, Bansal G, Cheng H, Mitchell JR, Dort JC. MRI texture analysis predicts p53 status in head and neck squamous cell carcinoma. AJNR Am J Neuroradiol. 2015 Jan;36(1):166-70. doi: 10.3174/ajnr.A4110. Epub 2014 Sep 25. PubMed PMID: 25258367.

Smith KA, Matthews TW, Dubé M, Spence G, Dort JC. Changing practice and improving care using a low-risk tracheotomy clinical pathway. JAMA Otolaryngol Head Neck Surg. 2014 Jul;140(7):630-4. doi: 10.1001/jamaoto.2014.921. PubMed PMID: 24921407.

Yeung JK, Dautremont JF, Harrop AR, Asante T, Hirani N, Nakoneshny SC, de Haas V, Mckenzie D, Matthews TW, Chandarana SP, Schrag C, Dort JC. Reduction of pulmonary complications and hospital length of stay with a clinical care pathway after head and neck reconstruction. Plast Reconstr Surg. 2014 Jun;133(6):1477-84. doi: 10.1097/PRS.0000000000000217. PubMed PMID: 24867729.

Badenduck LA, Matthews TW, McDonough A, Dort JC, Wiens K, Kettner R, Crawford S, Kaplan BJ. Fiber-optic endoscopic evaluation of swallowing to assess swallowing outcomes as a function of head position in a normal population. J Otolaryngol Head Neck Surg. 2014 Apr 22;43:9. doi: 10.1186/1916-0216-43-9. PubMed PMID: 24755159; PubMed Central PMCID: PMC4017766.

Dautremont JF, Rudmik LR, Yeung J, Asante T, Nakoneshny SC, Hoy M, Lui A, Chandarana SP, Matthews TW, Schrag C, Dort JC. Cost-effectiveness analysis of a postoperative clinical care pathway in head and neck surgery with microvascular reconstruction. J Otolaryngol Head Neck Surg. 2013 Dec 19;42:59. doi: 10.1186/1916-0216-42-59. PubMed PMID: 24351020; PubMed Central PMCID: PMC3878235.

Yeung JK, Harrop R, McCreary O, Leung LT, Hirani N, McKenzie D, de Haas V, Matthews TW, Nakoneshny S, Dort JC, Schrag C. Delayed mobilization after microsurgical reconstruction: an independent risk factor for pneumonia. Laryngoscope. 2013 Dec;123(12):2996-3000. doi: 10.1002/lary.24241. Epub 2013 Jun 28. PubMed PMID: 23754486.

Lysack JT, Hoy M, Hudon ME, Nakoneshny SC, Chandarana SP, Matthews TW, Dort JC. Impact of neuroradiologist second opinion on staging and management of head and neck cancer. J Otolaryngol Head Neck Surg. 2013 Jun 5;42:39. doi: 10.1186/1916-0216-42-39. PubMed PMID: 23739037; PubMed Central PMCID: PMC3680178.

Bose P, Klimowicz AC, Kornaga E, Petrillo SK, Matthews TW, Chandarana S,Magliocco AM, Brockton NT, Dort JC. Bax expression measured by AQUAnalysis is an independent prognostic marker in oral squamous cell carcinoma. BMC Cancer. 2012 Aug 1;12:332. doi: 10.1186/1471-2407-12-332. PubMed PMID: 22852863; PubMed Central PMCID: PMC3487960.

Doherty C, Nakoneshny SC, Harrop AR, Matthews TW, Schrag C, McKenzie DC, De Haas W, Davis RB, Dort JC. A standardized operative team for major head and neck cancer ablation and reconstruction. Plast Reconstr Surg. 2012 Jul;130(1):82-8. doi: 10.1097/PRS.0b013e3182547e22. PubMed PMID: 22743875.

Deutschmann MW, McDonough A, Dort JC, Dort E, Nakoneshny S, Matthews TW. Fiber-optic endoscopic evaluation of swallowing (FEES): predictor of swallowing-related complications in the head and neck cancer population. Head Neck. 2013 Jul;35(7):974-9. doi: 10.1002/hed.23066. Epub 2012 Jun 22. PubMed PMID: 22730220.

Brockton NT, Klimowicz AC, Bose P, Petrillo SK, Konno M, Rudmik L, Dean M, Nakoneshny SC, Matthews TW, Chandarana S, Lau HY, Magliocco AM, Dort JC. High stromal carbonic anhydrase IX expression is associated with nodal metastasis and decreased survival in patients with surgically-treated oral cavity squamous cell carcinoma. Oral Oncol. 2012 Jul;48(7):615-22. doi: 10.1016/j.oraloncology.2012.01.018. Epub 2012 Feb 25. PubMed PMID: 22366443.

Rudmik L, Lau HY, Matthews TW, Bosch JD, Kloiber R, Molnar CP, Dort JC. Clinical utility of PET/CT in the evaluation of head and neck squamous cell carcinoma with an unknown primary: a prospective clinical trial. Head Neck. 2011 Jul;33(7):935-40. doi: 10.1002/hed.21566. Epub 2010 Nov 12. PubMed PMID: 21674668.

Walen SG, Rudmik LR, Dixon E, Matthews TW, Nakoneshny SC, Dort JC. The utility of the harmonic scalpel in selective neck dissection: a prospective, randomized trial. Otolaryngol Head Neck Surg. 2011 Jun;144(6):894-9. doi: 10.1177/0194599811403874. Epub 2011 Mar 31. PubMed PMID: 21493266.

Everett JB, Falck VG, Dort JC, Matthews TW. Mandibular pseudoepitheliomatous hyperplasia following treatment for oral squamous cell carcinoma. J Otolaryngol Head Neck Surg. 2011 Feb;40(1):E1-4. PubMed PMID: 21303592.

Sowerby LJ, Matthews TW, Khalil M, Lau H. Primary large cell neuroendocrine carcinoma of the submandibular gland: unique presentation and surprising treatment response. J Otolaryngol. 2007 Aug;36(4):E65-9. PubMed PMID: 18684351.

Yunker WK, Matthews TW, Dort JC. Making the most of your pathology: standardized histopathology reporting in head and neck cancer. J Otolaryngol Head Neck Surg. 2008 Feb;37(1):48-55. PubMed PMID: 18479628.

Huber GF, Khalil M, Falck V, Matthews TW, Dort JC. Merkel cell carcinoma with solitary parotid metastasis: diagnostic dilemma in the absence of a primary site. J Otolaryngol Head Neck Surg. 2008 Feb;37(1):E19-21. PubMed PMID: 18479622.

Lau H, Phan T, Mackinnon J, Matthews TW. Absence of planned neck dissection for the N2-N3 neck after chemoradiation for locally advanced squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 2008 Mar;134(3):257-61. doi: 10.1001/archoto.2007.49. PubMed PMID: 18347249.

Huber GF, Khalil M, Falck V, Matthews TW, Dort JC. Merkel cell carcinoma with solitary parotid metastasis: diagnostic dilemma in the absence of a primary site. J Otolaryngol. 2007 Oct;36(5):E70-2. PubMed PMID: 18001635.

Huber GF, Dziegielewski P, Matthews TW, Warshawski SJ, Kmet LM, Faris P, Khalil M, Dort JC. Intraoperative frozen-section analysis for thyroid nodules: a step toward clarity or confusion? Arch Otolaryngol Head Neck Surg. 2007 Sep;133(9):874-81. PubMed PMID: 17875853.

Huber GF, Matthews TW, Dort JC. Radiation-induced soft tissue sarcomas of the head and neck. J Otolaryngol. 2007 Apr;36(2):93-7. PubMed PMID: 17459279.

Huber GF, Matthews TW, Dort JC. Soft-tissue sarcomas of the head and neck: a retrospective analysis of the Alberta experience 1974 to 1999. Laryngoscope. 2006 May;116(5):780-5. PubMed PMID: 16652087.

Heathcote JG, Matthews TW, Tsang W. Giant cell carcinoma of the hypopharynx: pathologic diagnosis and natural history. J Otolaryngol. 2004 Oct;33(5):322-6. PubMed PMID: 15931820.

Hamilton S, Venkatesan V, Matthews TW, Lewis C, Assis L. Computed tomographic volumetric analysis as a predictor of local control in laryngeal cancers treated with conventional radiotherapy. J Otolaryngol. 2004 Oct;33(5):289-94. PubMed PMID: 15931812.

Sherman D, Matthews TW, Lampe H, LeBlanc S. Laryngectomy clinical pathway: development and review. J Otolaryngol. 2001 Apr;30(2):115-20. PubMed PMID: 11770953.

Ringstrom E, Matthews TW, Lampe HB, Currie C. Role of percutaneous gastrostomy tubes in the postoperative care of patients with cancer of the oral cavity and oropharynx. J Otolaryngol. 1999 Apr;28(2):68-72. PubMed PMID: 10212871.

Lo SM, Venkatesan V, Matthews TW, Rogers J. Tumour volume: implications in T2/T3 glottic/supraglottic squamous cell carcinoma. J Otolaryngol. 1998 Oct;27(5):247-51. PubMed PMID: 9800621.

Sindwani R, Matthews TW, Thomas J, Venkatesan VM. Epithelioid leiomyosarcoma of the larynx. Head Neck. 1998 Sep;20(6):563-7. PubMed PMID: 9702545.

Tang AC, Raphael SJ, Lampe HB, Matthews TW, Becks GP. Expression of dipeptidyl aminopeptidase IV activity in thyroid tumours: a possible marker of thyroid malignancy. J Otolaryngol. 1996 Feb;25(1):14-9. PubMed PMID: 8816103.

Matthews TW, Lampe HB, Dragosz K. Nutritional status in head and neck cancer patients. J Otolaryngol. 1995 Apr;24(2):87-91. PubMed PMID: 7602677.