Dr. Sorana Morrissy

Publications

• Development and first-in-human CAR T therapy against the pathognomonic MiT-fusion driven protein GPNMB. Zemp FJ, Breckenridge Z, * Song H,* Gill GS,* Liu H, Suh Y, Guignard L, Pyczek J, John C, Mah L, Rajwani J, Louie T, Ellestad KK, Evseev D, Turk M, Benaoudia S, Alex J, Naumenko V, Thoppey Manoharan V, Kazemi Mehrabadi M, Smith HA, Gilbert GNY, Narta K, Gilmour A, Verhey TB, Todesco HM, Osz K, Ahn BY, Bogossian A, Anderson C, Bismar TA, DYC Heng, Lawson K, Lineham M, Pedersen H, Gordon P, McIntyre JB, MacGregor J, Brodeur-Robb K, Difrancesco L, Ogilvie T, Schöffski P, Wozniak A, Holt RA, Bell J, Senger D, Lewis V, Monument M, Potts K, Trpkov K, Hay K, Quizi J, Chan J, Saleh R, Henning JW, Prokopishyn N, Morrissy AS,* Shafey M,* Mahoney DJ*. medRxiv. (2025)
• SynNotch-gated CARs enhance specificity, promote persistence, and reduce toxicity in AML. Jambon S, Sun J, Barman S, Muthugounder S, Kovach A, Wood B, Thoppey Manoharan V, Morrissy AS, Bhojwani D, Wayne A, Pulsipher M, Kim YM, Asgharzadeh S, Parekh C, Moghimi B. . Blood Cancer Discovery. 6(1):55-72. (2025)
• Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma. Thoppey-Manoharan V, Abdelkareem A, Brown S, Gillmor A, Hall C, Seo H, Narta K, Grewal S, Dang NH, Ahn BY, Osz K, Lun X, Mah L, Zemp F, Mahoney D, Senger D, Chan JC, Morrissy AS.. Genome Biology. 25(1):264. (2024)
• Spatial and Single-Cell Transcriptomics Reveal that Oncofetal Reprogramming of Fibroblasts Is Associated with Malignant Degeneration of Burn Scar. Sinha S, Arora R, Kutluberk E, Verly M, Small C, Herik A, Burnett L, Cao L, Thoppey Manoharan V, Chockalingam K, van der Vyver M, Ponjevic D, Sparks HD, Morrissy S, Harrop AR, Brenn T, Nikolic A, Temple-Oberle C, Rosin N, Gabriel V, Biernaskie J. . Journal of Investigative Dermatology. 145(2):444-451. (2024)
• mosaicMPI: a framework for modular data integration across cohorts and -omics modalities. Verhey TB, Seo H, Gilmour A, Thoppey Manoharan V, Schriemer D, Morrissy AS. . Nucleic Acids Research. 52(12):e53. (2024)
• Mouse Model of Fragile X Syndrome Analyzed by Quantitative Proteomics: A Comparison of Methods. Filandrova R, Douglas P, Verhey T, Morrissy AS, Turner R, Schriemer D.. Journal of Proteomics Research. 22(9) 3054–3067. (2023)
• Profiling Chromatin Accessibility at Single-cell Resolution. Sinha S, Satpathy AT, Zhou W, Hongkai J, Stratton JA, Jaffer A, Bhalis N, Morrissy S, Biernaskie J. . Genomics Proteomics and Bioinformatics. (2021)
• Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancer.. Nikolic A, Singhal D, Ellestad K, Johnston M, Shen Y, Gillmor A, Morrissy S, Cairncross JG, Jones S, Lupien M, Chan JA, Neri P, Bahlis N, Gallo M. . Science Advances. (2021)
• The Transcriptome of Sonic Hedgehog Medulloblastoma. Skowron P*, Farooq H*, Cavalli FMG*, Morrissy AS*, Ly M, Hendrikse LD, Wang EY, Djambazian H, Zhu H, Mungall KL, Trinh QM, Zheng T, Shizhong D, Stucklin AG, Vladoiu MC, Fong V, Holgado BL, Nor C, Wu X, Abd-Rabbo D, Wang YC, Luu B, Suarez RA, Rastan A, Lee JJY, Zhang XY, Daniels C, Dirks P, Malkin D, Bouffet E, Bérubé P, Tabori U, Loukides J, Doz F, O’Delattre OO, Ayrault O, Kim S-K, Meyronet D, Grajkowska WA, Carlotti CG, de Torres C, Mora J, Eberhart CG, Van Meir CG, Kumabe T, French PJ, Kros JM, Jabado N, Lach B, Pollack IF, Hamilton RL, Nageswara Rao AA, Giannini C, Olson JM, László R, Klekner A, Zitterbart K, Phillips JJ, Thompson RC, Cooper MK, Rubin JB, Liau LM, Garami M, Hauser P, Li KKW, Ng H-K, Sang Poon W, Gillespie GY, Chan JA, Jung S, McLendon RE, Thompson EM, Zagzag D, Vibhakar R, Ra YS, Garre ML, Schüller U, Shofuda T, Faria CC, López-Aguilar E, Zadeh G, Hui CC, Ramaswamy V, Bailey SD, Jones SJM, Mungall AJ, Moore RA, Calarco J, Stein L, Bader GD, Reimand J, Ragoussis J, Weiss WA, Marra MA, Suzuki H, Taylor MD.. Nature Communications. (2021)
• Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis. Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, Chavez L, Yu C, Kurian KM, Magnaldo T, Sevenet N, Koch P, Pollard SM, Dirks P, Snyder MP, Largaespada DA, Cho YJ, Phillips JJ, Swartling FJ, Morrissy AS, Kool M, Pfister SM, Taylor MD, Smith A, Weiss WA. . Cell Stem Cell. 5(3):433-446. (2019)
• Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma. Hoffman M, Gillmor AH, Kunz DJ, Johnston MJ, Nikolic A, Narta K, Zarrei M, King J, Ellestad K, Dang NH, Cavalli FMG, Kushida MM, Coutinho FJ, Zhu Y, Luu B, Ma Y, Mungall AJ, Moore R, Marra MA, Taylor MD, Pugh TJ, Dirks PB, Strother D, Lafay-Cousin L, Resnick AC, Scherer S, Senger DL, Simons BD, Chan JA, Morrissy AS, Gallo M.. Cancer Research. 79(9):2111-2123. (2019)
• A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Garzia L*, Kijima N*, Morrissy AS*, Wu X, Wang X, Donovan LK, De Antonellis P, Liu K-W, Luu B, Alamsahebpour A, Thompson YY, Holgado BL, Ramaswamy V, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Manno A, Liu J, Qin L, Cybulsky M, Mitra S, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Bouffet E, Sorensen PHB, Aldape K, Marra MA, Wechsler-Reya RJ, Fults DW, Taylor MD. . Cell. 172(5):1050-62. (2018)
• The whole-genome landscape of medulloblastoma subtypes. Northcott PA*, Buchhalter I*, Morrissy AS*, Hovestadt V, Groebner S, Ehrenberger T, Segura-Wang M, Zichner T, Weischenfeldt J, Schumacher S, Phillips AH, Kleinheinz K, Waszak SM, Erkek A, Jones DTW, Worst BC, Kool M, Zapatka M, Jäger N, Chavez L, Hutter B, Bieg M, Paramasivam N, Heinold M, Gu Z, Warnatz H-J, Risch T, Amstislavskiy V, Weber U, Wolf S, Robinson GW, Zhou X, Wu G, Finkelstein D, Cavalli FMG, Luu B, Ramaswamy V, Wu X, Koster J, Ryzhova M, Cho Y-J, Pomeroy S, Herold-Mende S, Schuhmann M, Ebinger M, Liau LM, Mora J, McLendon RE, Jabado N, Kumabe T, Witt O, Milde T, Von Deimling A, Capper D, Korshunov A, Yaspo M-L, Kriwacki R, Gajjar A, Zhang J, Beroukhim R, Fraenkel E, Korbel JO, Brors B, Schlesner M, Eils R, Marra MA, Pfister SM, Taylor MD, and Lichter P.. Nature. 547(7663):311-7. (2017)
• Spatial Heterogeneity in Medulloblastoma. Morrissy AS*, Remke M*, Cavalli1 FMG*, Ramaswamy V, Shih DJH, Agnihotri S, Kiehna EN, Mercier E, Mayoh C, Papillon-Cavanagh S, Nikbakht H, Gayden T, Torchia J, Picard D, Merino D, Horswell S, Luu B, Wu X, Yao Y, Hovestadt V, Northcott PA, Jones DTW, Peacock J, Garzia L, Wang X, Mack SC, Reimand J, Albrecht S, Fontebasso AM, Thiessen N, Li Y, Schein JE, Lee D, Carlsen R, Mayo M, Tse K, Tam A, Dhalla N, Ally A, Chuah E, Cheng Y, Plettner P, Li HI, Corbett R, Wong T, Long W, Loukides J, Buczkowicz P, Hawkins CE, Tabori U, Rood BR, Myseros JS, Packer RJ, Korshunov A, Lichter P, Kool M, Pfister SM, Schüller U, Dirks P, Huang A, Bouffet E, Rutka JT, Bader GD, Swanton C, Ma Y, Moore RA, Mungall AJ, Majewski J, Jones SJM, Das S, Malkin D, Jabado N, Marra MA, Taylor MD.. Nature Genetics. 49:780-8. (2017)
• Divergent clonal selection dominates medulloblastoma at recurrence. Morrissy AS*, Garzia L*, Shih DJH, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FMG, Ramaswamy V, Lindsay P, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, Mungall KL, Yusanne M, Tse K, Zeng T, Shumansky K, Roth AJL, Shah S, Farooq H, Kijima N, Holgado BL, Lee JJY, Matan-Lithwick S, Liu J, Mack SC, Manno A, Michaelraj KA, Nor C, Peacock J, Qin L, Reimand J, Rolider A, Thompson YY, Wu X, Pugh T, Ally A, Bilenky M, Butterfied YSN, Carlsen R, Cheng Y, Chuah E, Corbett RD, Dhalla N, He A, Lee D, Li HI, Long W, Mayo M, Plettner P, Qian JQ, Schein JE, Tam A, Wong T, Birol I, Zhao Y, Faria CC, Pimentel J, Bendel AE, Fults DW, Walter AW, Kumabe T, Tominaga T, Collins VP, Cho YJ, Hoffman C, Lyden D, Wisoff J, Garvin JH, Stearns DS, Massimi L, Schuller U, Sterba J, Zitterbart K, Puget S, Ayrault O, Dunn SE, Tirapelli DPC, Carlotti CG, Wheeler H, Hallahan AR, Ingram W, MacDonald TJ, Olson JJ, Van Meir EG, Lee JY, Wang KC, Kim SK,Cho BK,Marra MA. Taylor MD. Nature. 529(7586): 351-7. (2016)