Dr. Sarthak Sinha
MD, PhD
Pronouns: He/Him
Positions
MD/PhD Candidate
Leaders In Medicine
Doctoral Researcher
Centre for Cell Therapy Translation
Contact information
Location
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Senior Communications Specialist
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Research
Areas of Research
Skin regeneration versus fibrosis
We leverage small (rodent) and large (reindeer) mammalian models of wound healing to understand how deep dermal injuries can regenerate new skin.
Single-cell genomics and bioinformatics
We employ cutting-edge single-cell and spatial genomics approaches to understand mechanisms driving skin scarring and regeneration.
Evidence-based wound care
We develop methods to quantify wound healing outcomes and systematically evaluate clinical evidence to provide guidance for wound care practitioners.
Participation in university strategic initiatives
Awards
- Vanier Canada Graduate Scholarship, Canadian Institutes of Health Research. 2019
- Izaak Walton Killam Laureate, University of Calgary. 2019
- Alberta Innovates Doctoral Studentship in Health Innovation, Alberta Innovates. 2021
- Zoetis Award for Outstanding Achievement, University of Calgary. 2020
Publications
- Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer. Cell. (2022)
- Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19. Nature Medicine. (2022)
- Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing. Cell Stem Cell. (2021)
- Fibroblasts: Origins, definitions, and functions in health and disease. Cell. (2021)
- A monocyte–leptin–angiogenesis pathway critical for repair post-infection. Nature. (2022)
- A B1a-natural IgG-neutrophil axis is impaired in viral-and steroid-associated aspergillosis. Science Translational Medicine. (2022)
- Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion. Science Advances. (2020)
- Profiling Chromatin Accessibility at Single-cell Resolution. Genomics, Proteomics & Bioinformatics. (2021)
- Transcriptional Analysis Reveals Evidence of Chronically Impeded ECM Turnover and Epithelium-to-Mesenchyme Transition in Scar Tissue Giving Rise to Marjolin's Ulcer . Journal of Burn Care & Research. (2017)
- Treating pain on skin graft donor sites: Review and clinical recommendations. Journal of Trauma and Acute Care Surgery. (2017)
- Epidemiological analysis of pediatric burns in the Dominican Republic reveals a demographic profile at significant risk for electrical burns. Burns. (2019)
- Interventions for postburn pruritus. Cochrane Database of Systematic Reviews. (2024)
In the News
- That ninth-grade science project really paid off. UCalgary News. (2019)
- Vet med scholars publish groundbreaking research on skin regeneration. UCalgary News. (2022)
- U of C researchers explore the regenerative properties of skin tissue through reindeer models. The Gauntlet. (2023)
- UCalgary study shows why drug used to treat critically ill COVID-19 patients may only benefit males. UCalgary News. (2021)
- U of T undergraduate student finds severe injuries result from cannabis oil production at home. U of T News. (2018)
- University of Calgary researchers lead comprehensive review on effective itch relief treatments for burn survivors. UCalgary News. (2024)
- University of Calgary study finds insights in skin regeneration after severe burns or injuries. CTV News. (2020)
- Immune Cell–Stem Cell Cooperation. The Scientist. (2016)
- Meet Calgary's youngest Top 40 Under 40. CBC News. (2013)
- Only in third year, and already in the Top 30 Under 30. U of T News. (2017)
- Canada's future leaders under 25. Macleans. (2013)
- Young scientist ahead of his time. Calgary Journal. (2013)
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