Dr. Pierre-Yves von der Weid
Cumming School of Medicine, Department of Physiology and Pharmacology
The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Lymphedema Research and Education Program
The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases
Inflammation Research Network
Libin Cardiovascular Institute
Gastrointestinal Research Group
Doctor of Philosophy Biological Sciences, University of Geneva, 1989
Diploma (B.Sc. Honours) Biology, University of Geneva, 1984
Areas of Research
The lymphatic system is composed of a dense network of lymphatic vessels, which plays vital roles in physiological processes such as tissue fluid homeostasis and transport of antigens and immune cells to and from lymphoid tissue. These two functions are critically important during inflammation to minimize the associated edema and initiate a proper immune response. My research program is focused on the physiology of the lymphatic system and on mechanisms related to the propulsion of lymph and alteration of these functions during inflammation and inflammatory diseases such as Crohn’s disease, arthritis and lymphedema.
- Generation of lymphatic pumping – origin of pacemaker potentials.
- Role of the endothelium and endothelium-released factors in modulation of lymphatic pumping.
- Modulation of lymphatic pumping and pacemaker potentials by vasoactive and inflammatory mediators.
- Modulation of lymphatic pumping and pacemaker potentials by vessel distention, transmural pressure and lymph flow.
- Identification of lymphatic mechanosensitive mechanisms and signalling pathways.
- Cross-talk between lymphatic vessels and immune cells.
- Interactions with immune cells.
- Alteration of lymphatic contractility and lymph flow during intestinal inflammation.
- Modulation by COX metabolites, nitric oxide and cytokines.
- Alteration of immune cell trafficking.
Participation in university strategic initiatives
|MDSC 620 LEC 01 01
|Topics in Systems Physiology
|Yearly - fall semester
|MDSC 755 LEC 03 03
- AHFMR Visiting Scientist from Alberta, 2009
- The Warren Veale Award, Dept of Physiology & Biophysics, 2005
- Novartis Prize for Young Scientist Best Poster, 1999
- Excellence Award for Best Oral Presentation, 1997
- Swiss Foundation for Grants in Medicine and Biology postdoc fellowship, 1995
- Swiss National Science Foundation postdoc fellowship, 1994
BHSc Honours Project student
Flavia Neto de Jesus, PhD
Matthew Stephens, PhD
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