Pierre-Yves von der Weid

Dr. Pierre-Yves von der Weid

Positions

Professor

Cumming School of Medicine, Department of Physiology and Pharmacology

Scientific Lead

The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Lymphedema Research and Education Program

Full Member

The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases

Full Member

Inflammation Research Network

Member

Libin Cardiovascular Institute

Member

Gastrointestinal Research Group

Contact information

Web presence

Phone number

Office: +1.403.220.7967
Lab: +1.403.220.2609

Location

Office: HSC 1645
Lab: HSC 1606

Background

Educational Background

Doctor of Philosophy Biological Sciences, University of Geneva, 1989

Diploma (B.Sc. Honours) Biology, University of Geneva, 1984

Research

Areas of Research

Lymphatic system functions and disfunction

The lymphatic system is composed of a dense network of lymphatic vessels, which plays vital roles in physiological processes such as tissue fluid homeostasis and transport of antigens and immune cells to and from lymphoid tissue. These two functions are critically important during inflammation to minimize the associated edema and initiate a proper immune response. My research program is focused on the physiology of the lymphatic system and on mechanisms related to the propulsion of lymph and alteration of these functions during inflammation and inflammatory diseases such as Crohn’s disease, arthritis and lymphedema.

Mechanisms of generation and modulation of lymphatic pumping.
  • Generation of lymphatic pumping – origin of pacemaker potentials.
  • Role of the endothelium and endothelium-released factors in modulation of lymphatic pumping.
  • Modulation of lymphatic pumping and pacemaker potentials by vasoactive and inflammatory mediators.
Basis of mechanical stimulation of lymphatic pumping.
  • Modulation of lymphatic pumping and pacemaker potentials by vessel distention, transmural pressure and lymph flow.
  • Identification of lymphatic mechanosensitive mechanisms and signalling pathways.
Chemical communication between lymphatic vessels and neighbouring tissues and cells.
  • Cross-talk between lymphatic vessels and immune cells.
  • Interactions with immune cells.
Lymphatic vessel functions in animal models of inflammation.
  • Alteration of lymphatic contractility and lymph flow during intestinal inflammation.
  • Modulation by COX metabolites, nitric oxide and cytokines.
  • Alteration of immune cell trafficking.

Participation in university strategic initiatives

Courses

Course number Course title Semester
MDSC 620 LEC 01 01 Topics in Systems Physiology Yearly - fall semester
MDSC 755 LEC 03 03 Directed Study 2020

Awards

  • AHFMR Visiting Scientist from Alberta, 2009
  • The Warren Veale Award, Dept of Physiology & Biophysics, 2005
  • Novartis Prize for Young Scientist Best Poster, 1999
  • Excellence Award for Best Oral Presentation, 1997
  • Swiss Foundation for Grants in Medicine and Biology postdoc fellowship, 1995
  • Swiss National Science Foundation postdoc fellowship, 1994

Publications

Yuki Ferguson
BHSc Honours Project student
yuki.ferguson@ucalgary.ca

Keith Keane
PhD Candidate
keith.keane@ucalgary.ca

Flavia Neto de Jesus, PhD
Postdoctoral Fellow
flavia.netodejesus@ucalgary.ca

Matthew Stephens, PhD
Research Associate
matthew.stephens@ucalgary.ca

Simon Roizes
Lab Manager
roizes@ucalgary.ca

Barbara Chyz
HSC 1663
Email: chyz@ucalgary.ca
Phone: 403.220.4555