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Dr. Nicolas Jacquelot, MSc, PhD

Positions

Assistant Professor

Cumming School of Medicine, Department of Biochemistry and Molecular Biology

Assistant Professor

Cumming School of Medicine, Department of Microbiology, Immunology and Infectious Diseases

Affiliations

Full Member

Arnie Charbonneau Cancer Institute

Full Member

Immunology Research Group

Contact information

Web presence

Phone number

Office: 403.210.9160

Location

Office: HMRB311

For media enquiries, contact

Kelly Johnston
Senior Communications Specialist

Please submit your media request here

 

Admin Assistant

Mary Marieno

Email: mmmarien@ucalgary.ca

Background

Educational Background

BSc. Cellular and Molecular Biology, Universite de Lorraine,

MSc. Immunology, Universite Paris Sud XI,

PhD. Cancer Immunology, Universite Paris Sud XI,

Biography

Dr. Nicolas Jacquelot completed his PhD in Cancer Immunology in the laboratory of Professor Laurence Zitvogel at Gustave Roussy Institute. His work has shed light on new molecular and cellular pathways that critically influence patient prognosis and immunotherapy outcomes. He pursued his postdoctoral training in Professor Gabrielle Belz’s group at The Walter and Eliza Hall Institute of Medical Research and in Professor Pamela Ohashi’s laboratory at the Princess Margaret Cancer Centre. In January 2023, he opened his own laboratory at the University of Calgary in the Cumming School of Medicine. His research has revealed the role and function of innate lymphoid cells in anti-tumor immunity and immunotherapy responses. Altogether, his studies have provided a better understanding of the role and function of immune lymphocytes, particularly T cells and the recently discovered innate lymphoid cells in cancer.

Research

Areas of Research

Area of Focus
  • Cancer Immunology
  • Immunotherapy
  • Innate Immunity
Summary of Research

Our laboratory is studying the role and function of the immune system in cancer. We examine the contribution of the innate lymphoid cells (ILCs) to tumor development and therapy responses. Despite their critical role in fighting infections and promoting inflammation driving autoimmune diseases, how ILCs, considered as the innate counterpart of adaptive lymphocytes, impact tumor development, progression and cancer treatments remain vastly unknown. We leverage our expertise in mouse models, tissue biology, tumor immunology, flow-cytometry, microscopy, and multi-omics analyses to perform experiments that test the role and function of ILCs in cancer. Ongoing research efforts include (i) investigating the cellular and molecular pathways influencing ILC function in tumors, (ii) dissecting ILC signaling pathways and communication with other cells within the tumor microenvironment, and (iii) determining ILC prognostic values and therapeutic potential in cancer. Our overreaching goal is to improve cancer patient prognosis through the development of ILC-based treatments.

Projects

Innate lymphoid cells in cancer.

Our laboratory is studying the role and function of the immune system in cancer. We examine the contribution of the innate lymphoid cells (ILCs) to tumor development and therapy responses. Despite their critical role in fighting infections and promoting inflammation driving autoimmune diseases, how ILCs, considered as the innate counterpart of adaptive lymphocytes, impact tumor development, progression and cancer treatments remain vastly unknown. We leverage our expertise in mouse models, tissue biology, tumor immunology, flow-cytometry, microscopy, and multi-omics analyses to perform experiments that test the role and function of ILCs in cancer. Ongoing research efforts include (i) investigating the cellular and molecular pathways influencing ILC function in tumors, (ii) dissecting ILC signaling pathways and communication with other cells within the tumor microenvironment, and (iii) determining ILC prognostic values and therapeutic potential in cancer. Our overreaching goal is to improve cancer patient prognosis through the development of ILC-based treatments.

Publications

Mary Marieno, Administrative Assistant

Amisha Verma, Undergraduate Student

Hobin Seo, MSc Graduate Student

Megan Kinzel, MSc Graduate Student

Huiyang Yu, PhD Candidate (University of Queensland, co-supervised with Dr. Belz)

Kaelie Bittorf, MD Student

Dr. Amrita Kaur, Laboratory Technician/Laboratory Manager

Dr. Qiutong (Angela) Huang, Postdoctoral Fellow