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Dr. Kim McBride

Pronouns: he/him


Department Head

Cumming School of Medicine, Department of Medical Genetics

Section Head, Clinical Genetics

Alberta Childrens Hospital

Child Health & Wellness Researcher

Alberta Children's Hospital Research Institute

Contact information


Office: HMRB224

I'm looking for...

Research partners

I am open for collaborations in the area of cardiovascular genetics, with a specific interest in identifying collaborators in the area of congenital heart disease.

Study participants

I am looking for individuals with congenital heart disease for participation in research.  Please visit:



Pediatrics, Royal College of Physicians and Surgeons of Canada,

Clinical Genetics, American Board of Genetics and Genomics,

Clinical Biochemical Genetics, American Board of Genetics and Genomics,

Educational Background

MD University of Saskatchewan,

Masters Clinical Scientist Training Program, Baylor College of Medicine,

Residency Pediatrics , Mayo Clinic,

Fellowship Clinical Genetics , Baylor College of Medicine,

Fellowship Biochemical Genetics, Baylor College of Medicine,


Areas of Research

Genetics of Congenital Heart Disease

The focus of my lab is to understand the causes of congenital heart disease (CHD). We recruit families with CHD, with a an emphasis to find those families with more than one individual with a CHD. Genome sequencing is used to identify potential disease causing variants, with a more recent methods exploring non-coding regions and machine learning analysis to pull out patterns of variants.  The lab then looks at the potential functional consequences using cell based assays, including cell lines differentiated from induced pluripotent stem cells, either isogenic or with variants edited into the lines by CRISPR/Cas9 techniques.

Rare disorders

Many individuals with rare disorders remain undiagnosed, or travel through a long odyssey to find the cause of their problems. Worse, few rare disorders have specific treatments. I am interested in discovering causes of rare disorders, learning about the disease through observation and natural history studies, and investigating treatments in clinical trials. I have been involved in a variety clinical trials for rare disorders, from preclinical studies, to phase 1 through phase 3 trials, with an emphasis on small molecules and gene transfer studies.

Participation in university strategic initiatives