Kenneth Kai-Sing Ng
Positions
Adjunct Professor
Contact information
Phone number
Office: +1 (403) 220-4320
Background
Educational Background
B.S. Biochemistry, University of Calgary, 1990
Doctor of Philosophy Biological Sciences, Stanford University, 1998
M.S. Biochemistry, University of Calgary, 1992
Research
Areas of Research
Our lab focuses on two different systems:
- RNA-dependent RNA Polymerases
RNA-dependent RNA polymerases are the central enzymes responsible for replicating the genomes of positive-stranded RNA viruses. Positive-stranded RNA viruses are the cause of many human diseases -- such as polio, the common cold, hepatitis A, hepatitis C, dengue fever, viral encephalitis (West Nile virus), viral gastroenteritis (Norwalk virus) and the recently discovered Severe Acute Respiratory Syndrome (SARS). Positive-stranded RNA viruses also cause many serious diseases in other animals (for example, foot-and-mouth disease, rabbit hemorrhagic disease, feline calicivirus disease, porcine respiratory and reproductive syndrome, and equine viral arteritis) and plants (for example, plum pox, barley yellow disease, potato virus Y).
- Caliciviruses
Carbohydrate-binding proteins
As a part of the Alberta Ingenuity Centre for Carbohydrate Sciences (AICCS), we interact extensively with five other labs at the University of Alberta and at the University of Calgary to pursue interdisciplinary research investigating the diverse functions of carbohydrates and carbohydrate-binding proteins
Here are some of the main systems that we are currently studying:
Clostridium difficile toxins -- We are characterizing carbohydrate-binding activities in these toxins to better understand their roles in the pathogenesis of antibiotic associated diarrhea and pseudomembranous colitis New England Journal of Medicine Editorial on highly toxigenic C. difficile strain causing recent outbreaks in Quebec and US Canadian Medical Association Journal news item on C. difficile outbreak in Montreal and Calgary -- July 6, 2004 Canadian Medical Association Journal review on C. difficile pathogenesis & treatment -- July 6, 2004 Serum Amyloid Protein -- We are collaborating with Dave Bundle and other members of the AICCS to develop carbohydrate ligands of SAP for use in treating Alzheimer's disease C-type lectins
Awards
- Faculty of Science Award of Excellence in Research, 2012
- NSERC Brockhouse Canada Prize for Interdisciplinary Research, 2012
- AHFMR Senior Scholar Award, 2007
- CIHR New Investigator, 2004
- AHFMR Scholar Award, 2002
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