Dr. Jongbok Lee
Positions
Assistant Professor
Cumming School of Medicine, Department of Biochemistry and Molecular Biology
Full Member
Arnie Charbonneau Cancer Institute
Child Health & Wellness Researcher
Alberta Children's Hospital Research Institute
Affiliations
Assistant Professor
Cumming School of Medicine, Department of Biochemistry and Molecular Biology
Contact information
Phone number
Office: 403.220.8693
Location
Office: Arthur J.E. Child Comprehensive Cancer Centre8th floor
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Funding
Study participants
Background
Biography
Dr. Jongbok Lee is an immunotherapy researcher who earned his Ph.D. at the University of Toronto, where he focused on studying a specific type of immune cell therapy called allogeneic CD3+ CD4- CD8- double-negative T cells (DNT) for treating acute myeloid leukemia (AML). He explored its safety and effectiveness using preclinical models and investigated its potential as an 'off-the-shelf' therapy.
After completing his Ph.D., he pursued post-doctoral research at the University Health Network. During this time, he demonstrated how DNT could be combined with other treatments like Venetoclax (a Bcl-2 inhibitor), Azacytidine (a hypomethylating drug), and CAR T-cell technology. His work aimed to understand how DNT interacts with AML and the mechanisms behind it.
Moreover, Dr. Lee played a vital role in a phase I clinical trial that showcased the feasibility, safety, and potential efficacy of allogeneic DNT therapy for AML patients who had relapsed after undergoing allogeneic hematopoietic stem cell transplantation.
Research
Areas of Research
- Immunology
- Cancer
- Cancer immunotherapy
- Double-negative T cell
- CAR-T cell therapy
- Adoptive T cell therapy
- Off-the-shelf adoptive T cell therapy using CD3+ CD4- CD8- double negative T cell
Dr. Lee aims to identify the underlying mechanisms involved in DNT-mediate anti-cancer activities to allow the development of more precise therapeutic approaches using DNTs. His research objective is to develop a novel ACT strategy using DNTs to positively impact patients’ lives.
Participation in university strategic initiatives
Projects
funded by CIHR, Kids Cancer Care, Cancer Research Society
funded by Arthur Child Innovation Catalyst Grant
funded by Leukemia & Lymphoma Society of Canada, C17, Ron Wigham Memorial Research Initiative for Myeloid Cancers
Publications
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