Jeffrey Van Humbeck

Jeffrey Van Humbeck

Positions

Assistant Professor

Faculty of Science, Department of Chemistry

Contact information

Email

jeffrey.vanhumbec1@ucalgary.ca

Web presence

Website

Phone number

Office: 403.220.3039

Location

Office: SB229A

Background

Educational Background

Bachelor's of Science (Honours) Chemistry, The University of Calgary, 2005

Master of Arts Chemistry, Princeton University, 2008

Ph.D Chemistry, Princeton University, 2011

Research

Areas of Research

Biological and medicinal chemistry
Chemical synthesis and catalysis
Activities

The Van Humbeck research group is focused on developing new catalysts and reactions systems that can address the challenge of site-selectivity organic chemistry. Using both organic and transition metal catalysis, we invent new approaches that predictably modify a single functional group in molecules where several competitive positions are present. Our initial work has focused on converting C-H bonds adjacent to azaheterocycles (an important pharmaceutical building block) into new C=O, C-N, and C-F bonds. Students will learn a wide range of synthetic skills, including air-free techniques, as well as moderns approaches to data acquisition and analysis using ‘Design-of-Experiments (DoE)’ tactics.

Courses

Course number Course title Semester
CHEM 351 LEC 01 01 Organic Chemistry I 2021
CHEM 59928 LEC 01 01 Selected Topics in Chemistry 2021
CHEM 65928 LEC 01 01 Sel Topics in Organic CHEM 2021

Publications

  • Concerning the Mechanism of the FeCl3-Catalyzed a-Oxyamination of Aldehydes: Evidence for a Non-SOMO Activation Pathway. David WC MacMillan; Jeffrey F Van Humbeck; Robert R Knowles; Scott P Simonovich. (2010)
  • A general approach to the enantioselective α-oxidation of aldehydes via synergistic catalysis.. David WC MacMillan; Scott P Simonovich; Jeffrey F Van Humbeck. (2012)
  • A Highly Site-Selective Radical sp3 Amination of Azaheterocycles. Jeffrey F Van Humbeck; Krysta A Dummit; Keith W Bentley. (2017)
  • A Highly Site-Selective Radical sp3 Amination of Azaheterocycles. Jeffrey F Van Humbeck; Krysta A Dummit; Keith W Bentley. (2018)
  • Combined Iron/Hydroxytriazole Dual Catalytic System for Site Selective Oxidation Adjacent to Heterocycles. Jeffrey F Van Humbeck; Ryohei Kameyama; Chaosheng Luo; Julian C Cooper. (2017)
  • Combined Iron/Hydroxytriazole Dual Catalytic System for Site Selective Oxidation Adjacent to Heterocycles. Jeffrey F Van Humbeck; Ryohei Kameyama; Chaosheng Luo; Julian C Cooper. (2018)
  • Benzylic Fluorination of Azaheterocycles Induced by Single Electron Transfer to Selectfluor®. Kelley E Danahy; Julian C Cooper; Jeffrey F Van Humbeck. (2017)
  • Benzylic Fluorination of Azaheterocycles Induced by Single Electron Transfer to Selectfluor®. Julian C Cooper; Jeffrey F Van Humbeck; Kelley E Danahy. (2018)
  • Directing Methylene Oxidation towards Azaheterocycles by Transition-Metal and Organic Catalysis. Jeffrey F Van Humbeck. (2017)
  • Directing Methylene Oxidation towards Azaheterocycles by Transition-Metal and Organic Catalysis. Jeffrey F Van Humbeck. (2018)
  • Extraction of Lanthanide and Actinide Ions from Aqueous Mixtures Using a Carboxylic Acid-Functionalized Porous Aromatic Framework. Tatiana V. Plakhova; Selvan Demir; Stepan N Kalmykov; Hideaki Shiwaku; Shuao Wang; Jeffrey R Long; David K Shu; Stefan G Minasian; Jeffrey F Van Humbeck; Nicholas K Brune; Guoxin Tiang; Jarad A Mason; Tolek Tyliszczak; Tsuyoshi Yaita. (2016)
  • Tetraarylboratepolymer networks as single-ion conducting solid electrolytes. Jeffrey R Long; William R Dichtel; Michael L Aubrey; Geoffrey W Coates; Rob Ameloot; Jeffreu F Van Humbeck; Alaaeedin Alsbaiee. (2015)
  • Recent Trends in Catalytic sp3 C-H Functionalization of Heterocycles. Milanpreet Kaur; Jeffrey Francis Van Humbeck Professor. (2019)
  • Ammonia Capture in Porous Organic Polymers Densely Functionalized with Brønsted AcidGroups. Brian M Wiers; Guanshang Zhu; Jeffrey F Van Humbeck; Xiaofei Jing; Jeffrey R Long; Thomas M McDonald. (2014)
  • New Radical Strategies for Site-Selective C-H Functionalization Adjacent to Heterocycles. Jeffrey F Van Humbeck; Keith W Bentley; Julian C Cooper; Ryohei Kameyama; Palliser Shomody; Kelley E Danahy; Chaosheng Luo; Krysta A Dummit. (2017)
  • New Radical Strategies for Site-Selective C-H Functionalization Adjacent to Heterocycles. Jeffrey F Van Humbeck; Ryohei Kameyama; Keith W Bentley; Kelley E Danahy; Chaosheng Luo; Krysta A Dummit; Palliser Shomody; Julian C Cooper. (2018)