Dr. Jacqueline McMillan

MD MSc FRCPC

Pronouns: she/her

Positions

Clinical Assistant Professor

Cumming School of Medicine, Department of Medicine | Geriatric Medicine

Member

Cumming School of Medicine, Department of Community Health Sciences

Contact information

mcmilljm@ucalgary.ca

Location

Foothills Medical Centre: 1103

Background

Credentials

MD, University of British Columbia, 2010

Msc, University of Calgary, 2018

FRCPC, Royal College of Physicians and Surgeons of Canada,

Educational Background

MD University of British Columbia,

Biography

Dr. Jacqueline McMillan is a Geriatrician and Clinician Scientist. She completed her Medical Degree at the University of British Columbia, followed by Internal Medicine and Geriatric Medicine training at the University of Calgary. Dr. McMillan completed the Royal College of Physicians and Surgeons Clinical Investigator Program and Master of Community Health Sciences, Health Services Research at the University of Calgary.

Her research focusses on older adults, with a specific focus on older adults with HIV. Particular areas of research interest for Dr. McMillan include frailty, polypharmacy, dementia, falls, and loneliness in older adults.

She is the site lead of the Canadian Longitudinal Study on Aging https://www.clsa-elcv.ca/ The CLSA s a large, national, long-term study of more than 50,000 individuals who were between the ages of 45 and 85 when recruited. These participants will be followed until 2033 or death. The aim of the CLSA is to find ways to help us live long and live well, and understand why some people age in healthy fashion while others do not. Calgary is one of 11 national Data Collection Sites for the CLSA.

Dr. McMillan is the associate Program Director of the University of Calgary Clinician Investigator Program. The CIP is an accredited program of the Royal College of Physicians and Surgeons of Canada. The CIP assists in the career development of clinician investigators in Canada. The program provides a formal postgraduate medical education pathway through integrated, structured, and rigorous research training. The training requires a minimum of two years of research intensive training that involves enrolment in a graduate degree program (graduate stream), to complete a thesis or equivalent, or in a postdoctoral fellowship program if the trainee already has a graduate degree (postdoctoral stream).

Research

Areas of Research

Geriatric Medicine, HIV

Participation in university strategic initiatives

Brain and Mental Health (2015-2021)

Infections, Inflammations and Chronic Diseases (2015-2021)

Publications

Interventions associated with reduced loneliness and social isolation in older adults: a systematic review and meta-analysis. 1. Peter Hoang, James A King, Sarah Moore, Kim Moore, Krista Reich, Harman Sidhu, Chin Vern Tan, Colin Whaley, Jacqueline M. McMillan. JAMA Network Open. (2022)
Predictors of reported alcohol intake during the first and second waves of the COVID-19 pandemic in Canada among middle-aged and older adults: Results from the Canadian Longitudinal Study on Aging (CLSA). . Jacqueline M. McMillan, David B. Hogan, Chantelle Zimmer, Nazmul Sohel, Christina Wolfson, Susan Kirkland, Lauren E. Griffith, Nicole E. Basta, Parminder Raina. . Canadian Journal of Public Health. (2022)
Potentially Inappropriate Medication use in Older Adults (≥50 years) living with Human Immunodeficiency Virus (HIV): A Cross-Sectional Study. . Jacqueline M. McMillan Laura Nino-Canon Shayna Campbell M. John Gill. . Canadian Journal of General Internal Medicine. (2022)
Assessment and Management of Older Patients with Transthyretin Amyloidosis Cardiomyopathy: Geriatric Cardiology, Frailty Assessment and Beyond. Biobelemoye Irabor, Jacqueline M. McMillan, Nowell M. Fine. Frontiers in Cardiovascular Medicine. (2022)
Factors Associated with Willingness to Receive a COVID-19 Vaccine among 23,819 Adults Aged 50 years and Older: An Analysis of the Canadian Longitudinal Study on Aging. Nicole E. Basta, Nazmul Sohel, Giorgia Sulis, Christina Wolfson, Geva Maimon, Lauren Griffith, Susan Kirkland, Jacqueline McMillan, Mary Thompson, Parminder Raina. American Journal of Epidemiology. (2022)
Multimorbidity Resilience and COVID-19 Pandemic Self-reported Impact and Worry Among Older Adults: A Study Based on the Canadian Longitudinal Study on Aging (CLSA). . Wister A, Li L, Cosco TD, McMillan J, Griffith LE, Kirkland S, Raina P. BMC Geriatrics. (2022)
Assessment of functional mobility after COVID-19 in adults aged 50 years or older in the Canadian Longitudinal Study on Aging. . 7. Beauchamp MK, Joshi D, McMillan JM, Erbas U, Griffith LE, Basta NE, Kirkland S, Wolfson C, Raina P. JAMA Network Open. (2022)
Influenza vaccination uptake among Canadian adults before and during the COVID-19 pandemic: An analysis of the Canadian Longitudinal Study on Aging (CLSA). . Sulis G, Basta NE, Wolfson C, Kirkland SA, McMillan J, Griffith LE, Raina P. Vaccine. (2022)
A longitudinal analysis of the impact of the COVID-19 pandemic on the mental health of older adults from the Canadian Longitudinal Study on Aging. . Raina P, Wolfson C, Griffith L, Kirkland S. McMillan J, Basta N, Joshi D, Erbas U, Sohel N, Maimon G, Thompson M. Nature Aging. (2021)
Risk Factors for Dementia Development, Frailty, and Mortality in Older Adults with Epilepsy – A Population-Based Analysis.. 10. Ann Subota, Nathalie Jette Colin B. Josephson Jacqueline M. McMillan Mark R. Keezer Arturo Gonzalez Izquierdo Jayna Holroyd-Leduc. Epilepsy and Behavior. (2021)
Association of Balance Function With All-Cause and Cause-Specific Mortality Among US Adults. Chao Cao W. Todd Cade Shengxu Li Jacqueline McMillan Christine Friedenreich Lin Yang. JAMA Otolaryngology-Head & Neck Surgery. (2021)
Plasma microRNAs are associated with domain-specific cognitive function in people with HIV. Aparicio Massanett J, Xu Y, Li Y, Colantuoni C, Dastgheyb R, Williams D, Asahchop E, McMillan J, Power C, Fujiwara E, Gill J, Rubin LH. AIDS. (2021)
Construct and Criterion-Related Validity of the Clinical Frailty Scale in Persons With HIV. Jacqueline M. McMillan M. John Gill Christopher Power Esther Fujiwara David B. Hogan Leah H. Rubin. JAIDS. (2021)
Frailty in Parkinson's disease: a systematic-review and meta-analysis. Jacqueline M. McMillan Quentin Michalchuk Zahra Goodarzi. Clinical Parkinsonism and Related Disorders. (2021)
Prevalence and Prognostic Significance of Frailty Among Patients with Transthyretin Amyloidosis Cardiomyopathy. Nowell M. Fine Jacqueline M. McMillan. Circulation: Heart Failure. (2021)
HIV diagnosed after 50 years of age. Jacqueline M. McMillan Leah H. Rubin M. John Gill. Canadian Medical Association Journal. (2020)
Comorbidities in older persons with controlled HIV infection: correlations with frailty index subtypes. Jacqueline M. McMillan M. John Gill Christopher Power Esther Fujiwara David B. Hogan Leah H. Rubin. . AIDS Patient Care and STDs. (2020)
Distinct risks, clinical characteristics and outcomes by age at time of Human Immunodeficiency Virus (HIV) diagnosis. Jacqueline M. McMillan M. John Gill Leah H. Rubin. HIV Medicine. (2020)
An Emerging Concern - High Rates of Frailty among Middle-aged and Older Individuals Living with HIV. Jacqueline M. McMillan M. John Gill Hartmut B. Krentz David B. Hogan. Canadian Geriatrics Journal. (2019)
Managing HIV Infection in Patients Older than Fifty Years. . Dr. Jacqueline M. McMillan Dr. Hartmut Krentz Dr. M. John Gill Dr. David B. Hogan. . Canadian Medical Association Journal. (2018)
Wolfram Syndrome: A Case Report and Review of Clinical Manifestations, Genetics, Pathophysiology and Potential Therapies. Dr. N. Toppings Dr. Jacqueline McMillan Dr. PY Au Dr. O. Suchowersky Dr. L. Donovan.. Case Reports in Endocrinology. (2018)
Impact of Pharmacological Treatment of Diabetes Mellitus on Dementia Risk: Systematic Review and Meta-Analysis. Dr. Jacqueline M. McMillan Bria S. Mele Dr. David B. Hogan Dr. Alexander A. Leung. BMJ Open Diabetes Research and Care. (2018)
Stakeholder Meeting: Integrated Knowledge Translation approach to address the caregiver support gap. Holroyd-Leduc JM, McMillan J, Jette N, Bremault-Phillips SC, Duggleby W, Hanson HM, Parmar J. Canadian Journal of Aging. (2017)
Management of Diabetes among frail older adults. . Jacqueline McMillan Jayna Holroyd-Leduc. Canadian Geriatrics Society CME Journal. (2015)
Management of insomnia and long-term use of sedative-hypnotic drugs in older patients. Jacqueline M. McMillan, Elizabeth Aitken and Jayna M. Holroyd-Leduc. Canadian Medical Association Journal. (2013)
Frailty and the impacts of the COVID-19 pandemic on community-living middle-aged and older adults: an analysis of data from the Canadian Longitudinal Study on Aging (CLSA). . Griffith LE, McMillan Jacqueline, Hogan DB, Pourfarzaneh S, Anderson LN, Kirkland S, Basta NE, van den Heuvel E, Raina P. . Age and Ageing. (2022)
Trajectories of the socioeconomic gradient of mental health: Results from the CLSA COVID-19 questionnaire study. Asada Y, Grignon M, Hurley J, Stewart SA, Smith NK, Kirkland S, McMillan JM, Griffith LE,Wolfson C, Raina P. Health Policy. (2023)
Persistent COVID-19 symptoms in community-living older adults from the Canadian Longitudinal Study on Aging (CLSA). . Griffith LE, Beauchamp M, McMillan Jacqueline, Borhan S, Oz UE, Wolfson C, Kirkland S, Basta NE, Thompson M, Raina P. . Communications Medicine. (2023)
Increased prevalence of loneliness and associated risk factors during the COVID-19 pandemic: findings from the Canadian Longitudinal Study on Aging (CLSA). . Kirkland SA, Griffith LE, Erbas Oz U, Thompson M, Wister A, Kadowaki L, Basta NE, McMillan J, Wolfson C, Raina P.. BMC Public Health. (2023)
Worsened ability to engage in social and physical activity during the COVID-19 pandemic and mental health: Longitudinal analysis from the Canadian Longitudinal Study on Aging. . Cosco T, Kervin L, Hopper S, McMillan J, Kirkland S, Wister A, Griffith L, Raina P, Basta N, Riadi I. . Innovations in Aging. (2023)
Baseline characteristics of a prospective cohort study of aging and cardiovascular diseases among people living with HIV. . Giguere K, Chartrand-Lefebvre C, Baril JG, Conway B, El-Far M, Falutz J, Harris M, Jenabian MA, Leipsic J, Loufty M, Mansour S, MacPherson P, Margolese S, McMillan JM, Monteith K, Murray MCM, Pick N, Thomas R, Trottier TB, Trottier S, Tsoukas C, Walmsley S, Wong A, Tremblay C, Durand M. . HIV Medicine. (2023)
The impact of loneliness and social isolation during COVID-19 on cognition in older adults: A scoping review. . Kassam, K and McMillan JM. . Frontiers in Psychiatry. (2023)
COVID-19 vaccine uptake among people with HIV: identifying characteristics associated with vaccine hesitancy. . Boschung K, Gill MJ, Krentz HB, Dalere J, Beckthold B, Fonseca K, Bakal JA, McMillan JM, Kanji J, Lang R. . Sci Rep. (2023)
The changing landscape of both causes and locations of death in a regional HIV population 2010-2021. . Krentz HB, Lang R, McMillan JM, Ody M, Gill MJ. . HIV Medicine. (2024)
Effect of age-friendly communities action plan on trajectories of older Canadians’ depressive symptoms between 2018 and 2020 : Multilevel results from the Canadian Longitudinal Study on Aging.. Levasseur, M., Naud, D., Menec, V., Dubois, M.-F., Wolfson, C., Griffith, L. E., Trottier, L., McMillan, J., Généreux, M., Roy, M., Couturier, Y., Raina, P., & CLSA Team. . INQUIRY: The Journal of Health Care Organization, Provision, and Financing.. (2024)
The Effects of Cognitive Ability, Mental Health, and Self-Quarantining on Functional Ability of Older Adults During the COVID-19 Pandemic: Results from the Canadian Longitudinal Study on Aging. . Gregory, M. A., Schaeffer, M. J., Reeves, J. T. H., Griffith, L. E., Wolfson, C., Basta, N. E., McMillan, J. M., Kirkland, S., Raina, P., Paterson, T. S. E., & Canadian Longitudinal Study on Aging (CLSA) Team. Journal of geriatric psychiatry and neurology. (2024)
Potentially modifiable risk factors for dementia and mild cognitive impairment: an umbrella review and meta-analysis. . Jones A, Ali MU, Kenny M, Mayhew A, Mokashi V, He H, Lin S, Yavari E, Paik K, Subramanian D, Dydynsky R, Aryal K, Correia RH, Dash D, Manis DR, O’Connell M, Liu-Ambrose T, Taler V, McMillan JM, Hogan DB, Kirkland S, Costa AP, Wolfson C, Raina P, Griffith L. . Dementia and Geriatric Cognitive Disorders. (2024)
Creation of a rehabilitation prediction rule: a prioritization procedure. . Wu P, Goodarzi Z, McMillan JM. Canadian Geriatrics Journal. (2025)
Perceptions of frailty in long-term care. . Kayla Atchison, Pauline Wu, Ann M. Toohey, Daniel Gaetano, Jacqueline McMillan, Jenna Naylor, Sharon Kaasalainen, Michelle Grinman, Vivian Ewa, Jessica Simon, James Silvius, Aynharan Sinnarajah, Beth Gorchynski, David B. Hogan, Jayna Holroyd-Leduc, Zahra Goodarzi.. Canadian Geriatrics Journal. (2025)
Is frailty the geriatric troponin?. McMillan JM, Falutz J. . Journal of the American Geriatric Society. (2025)
Perspectives on continuing care, from home care to long-term care, for older people living with HIV: a cross-sectional study. . McMillan JM, Dalere J, Naqvi F, Ewa V, Lang R, Brar R, Milaney K, Bakal JA, Krentz HB, Quail P, Shukalek C, Leal J, Hill NE, Randall M, Gill MJ. . Health Science Reports. (2025)

In the News

Polypharmacy Common Among Patients Aged 65 or Older With HIV. Medscape. (2022)
Canadians' Alcohol Intake Changed During the Pandemic. Medscape. (2022)
BABY BOOMERS NOW LESS THAN 25% OF CANADA'S POPULATION, 2021 CENSUS DATA SHOWS. Shaye Ganam 770 CHQR Radio. (2022)
Canadian Longitudinal Study on Aging COVID-19 Study. 770 CHQR More than Money Radio Show..