Ian Lewis

Ian Lewis

PhD

Positions

Director, Alberta Centre for Advanced Diagnostics

Faculty of Science

Alberta Innovates Translational Health Chair

Faculty of Science

Full Member

The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases

Background

Educational Background

Bachelor of Science (Summa Cum Laude), Biology, Fort Lewis College, 2003

Doctor of Philosophy, Biochemistry, University Wisconsin - Madison, 2010

Postdoctoral Fellow, Lewis-Sigler Institute , Princeton University, 2014

Visiting Fellow, Harvard T.H. Chan School of Public Health, Harvard University, 2024

Research

Areas of Research

Precision infection management (PIM)
Metabolic adaptations in Pseudomonas aeruginosa
Hemoglobin metabolism in the malaria parasite Plasmodium falciparum
New analytical tools for identifying and quantifying metabolites in complex mixtures
Activities

Infectious diseases account for the majority of deaths in developing countries and are among the ten leading causes of mortality in Alberta. The emergence of diverse drug resistant pathogens has made finding new antimicrobial therapies both a Canadian and global health priority. My laboratory investigates the connection between metabolic adaptation and virulence of human pathogens. The ultimate goal of this research is to develop new diagnostic methods to identify high risk patients and novel antimicrobial therapies to control infections. One of the key challenges my laboratory faces is unraveling the complex host-pathogen metabolic dynamics that occur during infections. To address this challenge, we use state-of-the-art mass spectrometry (MS) and nuclear magnetic resonance (NMR) technology to comprehensively quantify the flow of molecules between pathogens and their hosts. This metabolomics approach is a powerful strategy for connecting metabolic phenomena with specific genes and is essential for understanding the metabolic determinants of virulence.

Courses

Course number Course title Semester
BCEM 443 Metabolism Fall 2022

Awards

  • Innovation Award – Early Career Researcher, University of Calgary. 2021
  • Peak Scholar, University of Calgary. 2019
  • Compelling Calgarian of 2016, Calgary Herald. 2016
  • Alberta Innovates Chair in Translational Health, Alberta Innovates Chair in Translational Health. 2015
  • Graduate Mentoring Award, 2007

Publications

In the News

  • UofC study helps physicians battle dangerous bacteria.. CBC News. (2018)