Hamid Habibi

Hamid Habibi

Positions

Professor

Faculty of Science , Department of Biological Sciences

Member

Libin Cardiovascular Institute

Contact information

Email

habibi@ucalgary.ca

Phone number

Office: +1 (403) 220-5270

Location

Office: BI276

Background

Educational Background

B.S. Biological Sciences, University of Birmingham, 1979

Doctor of Philosophy Biological Sciences, University of Birmingham, 1983

Courses

Course number Course title Semester
CMMB 528A Research Project in Cellular, Molecular and Microbial Biology Fall 2022
CMMB 528B Research Project in Cellular, Molecular and Microbial Biology Winter 2023

Projects

Research Interests

Research in my laboratory is centered on the endocrine control of reproduction and growth. Emphasis is placed on two levels of regulatory systems: i) Control of pituitary gonadotropin and growth hormone gene expression by hypothalamic gonadotropin-releasing hormone (GnRH) and gonadal steroids, and ii) paracrine regulation of ovarian function by GnRH and growth factors. My research provided novel information on GnRH functional diversity in a number of cell types of fish and mammalian origin and developed technologies relevant to pharmaceutical and agri-food industries. These include development of: 1) novel GnRH agonists with improved ovulatory and antitumor properties, and 2) method for enhancing growth rate in cultured fish species, using transgenic canola seeds expressing fish growth hormone. 

Awards

  • Visiting Professorship, Università Politecnica delle Marche, Italy. 2015
  • Achievement in innovation, 2013
  • Faculty of Science Award of Excellence in Community Outreach, 2012
  • Recognition award from International Conference on Anthropogenic impact on the Environment and Bioremediation, 2012
  • 18th Khwarazmi International Distinguished Research Award, Research Organization for Science and Technology.. 2005
  • Faculty of Science Distinguished Lecture, The University of Calgary. 2004
  • Faculty of Science Distinguished Lecture, 2004
  • Research Achievement Recognition-Celebration of Excellence, University of Calgary, 2002
  • Grace Pickford Medal, 2001
  • Professorship/Lectureship in Science and Sustainable Development, UNESCO and Thirdworld Academy of Science, 2001
  • Professorship/Lectureship in Science and Sustainable Development, UNESCO and International Council of Science / the World Academy of Sciences. 2000
  • Faculty of Science Research Fellowship, The University of Calgary. 1998
  • University Research Fellowship, Natural Sciences and Engineering Research Council, The University of Calgary. 1997
  • Postdoctoral Fellowship, Alberta Heritage Foundation for Medical Research. 1988
  • Postgraduate Studentship, Aston University. 1982

Publications

  • Integrated control of reproductive and growth phase in goldfish, hormonal effects on gene expression of the pituitary and peripheral tissues.. HR Habibi; Y Ma; J P Chang; C Ladisa. (2018)
  • Cylindrospermopsin impairs zebrafish (Danio rerio) development and gene expression. S. Shah; H. R. Habibi; A.C.N. Moraes; V.F. Magalhães. (2018)
  • Reproductive impairment of fathead minnows downstream of wastewater treatment plants, in the Bow River, Calgary, Alberta. HR. Habibi; HP. Fallah; V. Patel; MM. Vijayan. (2018)
  • Paracrine control of spermatogenesis by GnRH and GnIH in zebrafish (Danio rerio). Habibi H.R.; Nóbrega R.H.; Tovo N.A.; Fallah H.P.. (2018)
  • Paracrine control of germinal stem cell development and spermatogenesis by GnIH in zebrafish (Danio rerio).. RH Nóbrega; HR Habibi; H P Fallah; M S Rodrigues. (2019)
  • Cortisol and thyroid hormones: “new” players of zebrafish spermatogenesis.. A Tovo-Neto; M.S Rodrigues; H. R. Habibi; R.H Nóbrega. (2019)
  • Role of Thyroid Hormones in zebrafish spermatogenesis.. M.S Rodrigues; A Tovo-Neto; R.H Nóbrega; H. R. Habibi. (2019)
  • Metabolic profiling of male goldfish liver reveals patterns of energy allocation in support of growth and reproduction. C Ladisa; Y Ma; H R Habibi. (2019)
  • Integrated control of reproductive and growth phase in female goldfish, hormonal effects on release of the pituitary gonadotropin and growth hormone and gene expression. HR Habibi; Y Ma; C Ladisa; J P Chang. (2019)
  • Cylindrospermopsin impairs spermatogenesis and gene expression in zebrafish testis. H. P. Fallah; V.F. Magalhães; H. R. Habibi; A.C.N. Moraes. (2019)
  • LC-MS based metabolic profiling reveals patterns of energy allocation in support of the metabolic shift between growth and reproduction in goldfish. H R Habibi; Y Ma; C Ladisa. (2019)
  • A link between environmental contaminants in Southern Alberta Rivers andphysiological consequences disrupting reproduction and metabolism in fish.. A* Zare; J* Jordan; A M Weljie; Leland J Jackson; H R Habibi; S* Henderson. 1 page. (2011)
  • Population genetic consequences of endocrine disruptingcompounds on longnose dace (Rhinichthys cataractae) in Alberta.. E Crispo; H Tunna; Leland Jackson; H Habibi; Sean M Rogers. 1 page. (2011)
  • Cylindrospermopsin impairs Zebrafish (Danio rerio) Development and gene expression. H. R. Habibi; S. Shah; V.F. Magalhães; A.C.N. Moraes. (2018)
  • Reproductive impairment of fathead minnows in the bow river downstream of wastewater treatment plant in the City of Calgary.. Vaibhav Patel; H R Habibi; Matt (Mathilakath) M Vijayan; H P Fallah; H R Habibi; J P Chang. (2017)
  • Gonadotropin inhibitory hormone control of gonadotropin hormoneproduction in goldfish.. J P Chang; M* Moussavi; M* Wlasichuk; H R Habibi. 1 page. (2013)
  • Gonadotropin inhibitory hormone control of gonadotropin hormoneproduction in goldfish.. M* Wlasichuk; M* Moussavi; H R Habibi; J P Chang. 1 page. (2013)
  • Gonadal GnRH & GnIH are involved in paracrine control of testicular development & spermatogenesis in zebrafish (Danio rerio).. J P Chang; H P Fallah; HR Habibi; H R Habibi; Tovo Neto A; R H Nobrega. (2017)
  • Assessingthe health impact of phosphate bio-stimulated OSPW on embryonic zebrafish(Danio rerio).. R ., Hamid; Habibi; Lindsay Clothier; Gordon Chua; Lisa Gieg; Cameron* Toth. 1 page. (2016)
  • Monitoring ofEnvironmental Contaminants in Southern Alberta Rivers, and Implementation of aMultidisciplinary University Partnership with the City of Calgary to AdvanceWastewater Treatment Technologies.. H R Habibi; Leland J Jackson. 1 page. (2011)
  • Endocrine disrupting chemicals cause metabolic dysregulation inadult male goldfish. Received Student Award and chosen for Platform presentation.. H R Habibi; Leland J Jackson; J* Jordan; A M Weljie; F* Pang; A* Zare. 1 page. (2010)
  • Regulation of gene expression in goldfish liver and gonads byenvironmentally relevant endocrine disrupting compounds.. Leland J Jackson; A* Zare; H R Habibi. 1 page. (2010)
  • Hormone sensitivity ofgoldfish tissue: a step towards endocrine disrupting chemical metabolomics.. A M Weljie; E* Allan; Leland J Jackson; B Edwards; F* Pang; J* Jordan; H R Habibi. 1 page. (2010)
  • Gonadotropininhibitory hormone regulation of gonadotropin production in goldfish.. M* Moussavi; M* Wlasichuk; G* Chahal; H R Habibi; J P Chang; Pang FY*. 1 page. (2010)
  • Assessing the health impact of OSPW onembryonic zebrafish (Danio rerio).. Gordon Chua; C* Both; H R Habibi; Lisa Gieg; L Clothier. 1 page. (2015)
  • Presence of Environmental contaminants in Souther Alberta Rivers:monitoring, risk assessment and remediation.. A Weljie; Leland J Jackson; S* Henderson; J* Jordan; A* Zare; H R Habibi. 1 page. (2012)
  • Brain metabolic disruption and neurotransmitters imbalance by low environmental concentration of environmentalcontaminants in the goldfish.. J* Jordan; A Weljie; A* Zare; H R Habibi. 1 page. (2012)
  • Gonadotropin inhibitory hormonemediated control of gonadotropin production in goldfish.Buenos Aires. M* Wlasichuk; H R Habibi; M* Moussavi; J P Chang. 1 page. (2012)
  • Native isoforms of gonadal GnRH are involved in the paracrine/autocrine control of testicular development and spermatogenesis in Zebrafish (Danio rerio). H P Fallah; HR Habibi. (2018)
  • Emerging contaminants cause adversehealth effects in native species of fish in Southern Alberta Rivers.. Meir (Kinch) C*; A Weljie; S* Henderson; H R Habibi; Leland J Jackson; J* Jordan. 1 page. (2012)
  • Microarray applications to investigate the impacts of exposureto environmental contaminants in male fathead minnows.. D Henry; Gordon Chua; A* Zare; H R Habibi. 1 page. (2015)
  • The role of thyroid hormones (T3 and T4) in zebrafish spermatogenesis is mediated by nuclear receptor in germ cells.. H P Fallah; R H Nobrega; Tovo Neto A; J P Chang; H R Habibi; H R Habibi. (2017)
  • Thyroid hormone control of reproduction ingoldfish.. Nelson ER*; H R Habibi; Allan ERO*; Pang FY*. 1 page. (2011)
  • How does bisphenol-A modulate reproductive physiology performances in male fish?. A* Zare; H R Habibi; A* Hate; Alavi SMH; A Abdulfatah; O. Linhart; P Fontaine. 1 page. (2011)
  • Effects of the mycotoxin zearalenone on reproduction endocrine disruption in zebrafish.. H R Habibi; M Sellamni; HR Habibi; K Krishna; J P Chang; H P Fallah. (2017)
  • Effects of methimazole-induced hypothyroidism in zebrafish spermatogenesis. D.F Costa; E.R.M Martinez; A Tovo-Neto; M.S Rodrigues; L.B Doretto; M.A Oliveira; H.R Habibi; R.H. Nóbrega; J.M.B Ricci. (2018)
  • Cortisol stimulates zebrafish spermatogenesis by modulating sertoli and leydig cell functions in an androgen-independent manner.. H. R Habibi; A. G Melo; E. Martinez; M. S Rodrigues; J. Ricci; A Tovo-Neto; M. A Oliveira; R. H. Nóbrega; l. B Doretto; A. J Butzge; D. F Costa. (2018)
  • Methimazole-induced hypothyroidism in zebrafish males: crossotalk between thyroid and reproduction,. Rodrigues; Habibi; Fallah; Tovo-Neto. (2018)
  • Regulation of metabolism during reciprocal control of reproduction and growth in goldfish. H R Habibi; C Ladisa; Y Ma. (2018)
  • Health Impacts of Sulfolane on Embryonic Development of Zebrafish. Hamid R. Habibi; Gopal Achari; Soham Shah. (2018)
  • Nuclear estrogen and thyroid hormone receptorstructural and functional diversity in goldfish.. Konschuh SA*; H R Habibi. 1 page. (2012)
  • Membrane associated thyroid hormone receptorsmediate development and angiogenesis in zebrafish.. Sarah Childs; Konschuh SA*; H R Habibi. 1 page. (2012)
  • Endocrine disrupting chemicals disruptmetabolism in male goldfish.. A* Zare; A M Weljie; A* Pang; J* Jordan; H R Hamid; Leland J Jackson. 1 page. (2010)
  • Exposure toBisphenol A affects hypothalamic neurogenesis in a region-specific manner inembryonic zebrafish. Abstract selected for oral presentation and award receivedfor “Best short talk (from selected abstracts). Deborah M Kurrasch; Kinch CD*; H R Habibi. 1 page. (2013)
  • Environmental Toxicology; Biomonitoring and remediation.. H R Habibi. 1 page. (2012)
  • Metabolomic Profiling of Follicular LymphomaA Proof-of-Principle Study. Mohammad Mehdi Banoei; Meer-Taher Shabani-Rad; Etienne Mahe; Hamid Habibi; Douglas Stewart; Adnan Mansoor. (2018)
  • Integrated control of reproduction and gametogenesis in fish. H P Fallah; H R Habibi; Tovo Neto A; RH Nóbrega. (2018)

Google Scholar Link

More Information

Additional publications

  • Kinch CD , Ibhazehiebo K, Jeong JH, Habibi HR, KurraschDM (2015) Low Dose Exposure to Bisphenol A and Replacement Bisphenol S Induces Precocious Hypothalamic Neurogenesis in Embryonic Zebrafish, PNAS, in press.

  • Moussavi M, Wlasichuk M, Chang J.P, and Habibi H.R. (2014) Gonadotropin-Inhibitory hormone (GnIH), Gonadotrophin releasing hormone, Growth hormone, Pitutitary, goldfish. J. Endocrinology, in press.   

  • Golshan M, Hatef A, Zare A, Socha M, Milla S, Gosiewski G, Fontaine P,  Sokołowska-Mikołajczyk M, Habibi HR, Alavi H (2014) Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo. Aquatic Toxicology, 155C:73-83. doi: 10.1016/j.aquatox.2014.06.004

  • Hontela A and Habibi HR (2014) Personal care products in the aquatic environment:  a case study on the effects of Triclosan in fish. Fish Physiology, 33: Organic Chem. Tox. Fishes, ISBN: 978-0-12-398254-4, (Tierney K, Farrell T, Brauner C, eds), 411-437 pp.

  • Habibi HR (2014) Environmental contaminants with hormone-like activity: Screening and risk characterization. Canadian Civil Engineer, 31.2: 20-23.

  • Annett R, Habibi HR, Hontela A (2014) Impact of glyphosate and glyphosate-based herbicides on the freshwater environment. Journal of Applied Toxicology, J Applied Toxicol. 34(5):458-479.

  • Shin HS, Habibi HR, Choi CY (2014) The environmental regulation of maturation in goldfish, Carassius auratus: Effects of various LED light spectra. Comp Biochem Physiol A Mol Integr Physiol. 168:17-24.

  • Shin HS, Kim NN, Choi YJ, Habibi HR, Kim JW, Choi CY (2013) Light-emitting diode spectral sensitivity relationship with reproductive parameters and ovarian maturation in yellowtail damselfish, Chrysiptera parasema. J Photochem Photobiol B. 127:108-13.

  • Nelson ER and Habibi (2013) Estrogen receptor function and regulation in fish and other vertebrates. General and Comparative Endocrinology, 192:15-24.

  • Kim NN, Lee J, Habibi HR, Choi CY (2013) Molecular cloning and expression of caspase-3 in the protandrous cinnamon clownfish during sex change. Fish Physiol Biochem, 39(3):417-29.

  • Moussavi M, Wlasichuk M, Chang J.P, and Habibi H.R. (2013) Seasonal effect of GnIH on GnRH-induced gonadotroph functions in the goldfish pituitary. J. Neuroendocrinol 25(5):506-516

  • Evans JS, Jackson LJ, Habibi HR, Ikonomou MG (2012) Feminization of longnose dace (Rhinichthys cataractae) in the Oldman River, Alberta (Canada) provides evidence of widespread endocrine disruption in an agricultural basin. Scientifica, Volume 2012, Article ID 521931, 11 pages http://dx.doi.org/10.6064/2012/521931

  • Hatef A, Zare A, Hadi Alavi, SM, Habibi HR, Linhart O (2012) Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to Bisphenol A. Environmental Toxicology and Chemistry 31(9):2069-2077.

  • Allan ERO and Habibi HR (2012) Direct effects of triiodothyronine on production of anterior pituitary hormones and gonadal steroids in goldfish. Mol Reprod & Development 79(9):592-602.

  • Kim NN, Habibi HR, Lee J, Choi CY (2012) Effects of recombinant gonadotropin hormones on the expression of vitellogenin, gonadotropin subunits and gonadotropin receptors in cinnamon clownfish, Amphiprion melanopus. Comp Biochem Physiol B 162(4):73-80

  • Jordan J, Zare A, Jackson LJ, Habibi HR, Weljie AM (2012) Exposure to low concentrations of waterborne contaminants, individually and in a mixture, causes disruption in metabolism in fish.  Journal of Proteome Research 11(2):1133-1143.

  • Moussavi M, Wlasichuk M, Chang JP, and Habibi HR (2012) Seasonal effect of GnIH on gonadotrope functions in the pituitary of goldfish, Mol. & Cellular Endocrinology 350(1):53-60.

  • Nelson ER, Allan ER, Pang FY, Habibi HR (2011) Auto-regulation of thyroid hormone receptors in the goldfish ovary and testis. Gen Comp Endocrinol 172:50-56

  • Jeffries KM, Jackson LJ, Ikonomou MG, Habibi HR (2010) Presence of natural and anthropogenic organic contaminants and potential fish health impacts along two river gradients in Alberta, Canada. Environmental Toxicology & Chemistry 29(10):2379-8.

  • Nelson ER, Allan ERO, Pang F and Habibi HR (2010) Thyroid Hormone and Reproduction: Regulation of Estrogen Receptors in Goldfish Gonads, Molecular Reproduction and Development, 77(9):784-94.

  • Nelson ER and Habibi HR (2010) Functional significance of estrogen receptor subtypes in the liver of goldfish. Endocrinology 151: 1668–1676.

  • An KW, An MI, Nelson ER, Habibi HR, Choi CY* (2009) Gender-related expression of TRalpha and TRbeta in the protandrous black porgy, Acanthopagrus schlegeli, during sex change processes. General and Comparative Endocrinology 65:11-8

  • Moussavi M, Nelson ER and Habibi (2009) Seasonal regulation of vitellogenin by growth hormone in the goldfish live. General and Comparative Endocrinology,161(1):79-82.

  • Nelson ER and Habibi (2009) Thyroid receptor subtypes: structure and function in fish. General and Comparative Endocrinology, 161(1):90-96

  • Chang JP, Johnson JD, Sawisky GR, Grey CL, Mitchell G, Booth M,  Volk MM, Parks SK,  Thompson E, Goss GG, Klausen C, Habibi HR (2009) Signal transduction in multifactorial neuroendocrine control of gonadotropin secretion and synthesis in teleosts - studies on the goldfish model. General and Comparative Endocrinology, 161(1):42-52

  • Nelson ER, Habibi HR. (2008) Functional significance of a truncated thyroid receptor subtype lacking a hormone-binding domain in goldfish. Endocrinology 149(9):4702-4710

  • Jeffries KM, Nelson ER, Jackson LJ, Habibi HR. (2008) Basin-wide impacts of compounds with estrogen-like activity on longnose dace (Rhinichthys cataractae) in two Prairie Rivers of Alberta, Canada. Environmental Toxicology and Chemistry, 27:2042–2052.

  • An KW, Nelson ER, Habibi HR, Choi CY* (2008) Molecular characterization and expression of three GnRH forms mRNA during gonad sex-change process, and effect of GnRHa on GTH subunits mRNA in the protandrous black porgy (Acanthopagrus schlegeli). General and Comparative Endocrinology 159:38-45.

  • Nelson ER and Habibi HR (2008) Seasonal-related homologous regulation of goldfish liver Estrogen receptor subtypes. Cybium 32(2): 248-25 .

  • Klausen C, Booth M, Habibi HR, Chang JP (2008) Extracellular signal-regulated kinase mediates gonadotropin subunit gene expression and LH release responses to endogenous gonadotropin-releasing hormones in goldfish. Gen Comp Endocrinol. 158(1):36-46.

  • An KW, Nelson ER, Jo PG, Habibi HR, Shin HS, Choi CY* (2008) Characterization of estrogen receptor beta2 and expression of the estrogen receptor subtypes alpha, beta1, and beta2 in the protandrous black porgy (Acanthopagrus schlegeli) during the sex change process. Comp Biochem Physiol B Biochem Mol Biol. 150(3):284-91.

  • Choi CY*, An KW, Nelson ER, Habibi HR. (2007) Cadmium affects the expression of metallothionein (MT) and glutathione peroxidase (GPX) mRNA in goldfish, Carassius auratus. Comp Biochem Physiol C Toxicol Pharmacol. 145(4):595-600.

  • Nelson ER, Wiehler WB, Cole WC, Habibi HR (2007) Homologous regulation of estrogen receptor subtypes in goldfish (Carassius auratus). Mol Reprod Dev. 74(9):1105-12.

  • Soverchia L, Carotti M, Andreu-Vieyra C, Mosconi G, Cannella N, Habibi H, Polzonetti-Magni AM. (2007) Role of gonadotropin-releasing hormone (GnRH) in the regulation of gonadal differentiation in the gilthead seabream (Sparus aurata). Mol Reprod Dev. 74(1):57-67.

  • Habibi HR and Andreu-Vieyra CV (2007) Hormonal Regulation of Follicular atresia in the teleost fish. In: The Fish Oocyte: From Basic Studies to Biotechnological Applications. (Babin, PJ, Cerda, J and Lubzens E eds.), Springer Pub Co., pp 231-250.