Douglas Gordon Storey
Positions
Adjunct Professor
Cumming School of Medicine, Department of Microbiology, Immunology and Infectious Diseases
Associate Member
The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases
Professor Emeritus
Contact information
Background
Educational Background
B.S. Microbiology, University of British Columbia, 1978
Doctor of Philosophy Microbiology, University of Ottawa, 1986
M.S. Microbiology, University of Western Ontario, 1981
Research
Areas of Research
The bacteria Pseudomonas aeruginosa is an opportunistic pathogen in humans causing severe and sometimes life-threatening infections. In individuals with cystic fibrosis, a common genetic disease, Pseudomonas aeruginosa is able to infect and colonize the lungs. This chronic infection and the host's immune response progressively damages the lung tissue resulting in a loss of lung function. The long-term goal of our research is to understand how the bacteria are able to infect and colonize the lungs of cystic fibrosis patients and to develop new approaches to control these infections.
Awards
- Risk Shining Star, University of Calgary. 2017
- Faculty of Science Teaching Excellence, 2015
- Nomination Faculty of Science Teaching Excellence, 2014
- Nominated for GSA Teaching excellence award, 2008
- Nominated for SU teaching award, 2005
More Information
Publications
- Erickson, D.L., Endersby, R., Kirkham, A., Stuber, K., Vollman, D.D., Rabin, H.R., Mitchell, I. and D.G. Storey. 2002. Pseudomonas aeruginosaquorum-sending systems may control virulence factor expression in the lugns of patients with Cystic Fibrosis. Infection and Immunity 70: 1783-1790.
- Hunt, T.A., Peng, W.-T., Loubens, I. and D.G. Storey. 2002. The Pseudomonas aeruginosa alternative sigma factor PvdS controls exotoxin A expression and is expressed in lung infections associated with Cystic Fibrosis. Microbiology 148: 3183-3193.
- Parkins, M.D., Altebaeumer, M., Ceri, H. and Storey, D.G. 2001. Subtractive hybridization based identification of genes uniquely or hyper-expressed during biofilm growth. In Doyle (eds), Methods in Enzymology 336:76-84
- Ceri, H., Olson, M.E., Morck, D., Storey, D., Read, R., and B. Olson. 2001. The MBECTM assay system: Multiple equivalent biofilms for antibiotic and biocide susceptibility testing. In Doyle (eds), Methods in Enzymology 337:377-385
- De Kievit, T.R., Parkins, M.D., Gillis, R.J., Srikumar, R., Ceri, H., Poole, K., Iglewski, B.H. and Storey, D.G. 2001. Multidrug Efflux Pumps: expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy 45: 1761-1770.
- Parkins, M.D., Ceri, H., and Storey, D.G. 2001. Pseudomonas aeruginosa GacA, a factor in multihost virulence, is also essential for biofilm formation. Molecular Microbiology. 40: 1215-1226
- Gallant, C., T.L. Raivio, J.C. Olson, D.E. Woods and D.G. Storey. (2000). Characterization of inactive exotocin A produced by Pseudomonas aeruginosa isolates from cystic fibrosis patients. Microbiology 146: 1891-1899.
- Hongjiang Yang, M. Matewish, I. Loubens, D.G. Storey, J.S. Lam and Shouguang Jin. (2000). migA, a quorum responsive gene of Pseudomonas aeruginosa is highly expressed in cystic fibrosis lung environment and modifies low-molecular-weight lipopolysaccharide. Microbiology 146: 2509-2519.
- Bruno, T.F., D.E. Woods, D.G. Storey and C.H. Mody. 1999. Recombinant Pseudomonas exoenzyme S and exoenzyme S from Pseudomonas aeruginosa DG1 share the abiilty to stimulate T lymphocyte proliferation. Can. J. Microbiol. 45: 607-611.
- Barclay, N.G., J.C.L. Spurell, T.F. Bruno, D.G. Storey, D.E. Woods and C.H. Mody. 1999. Pseudomonas aeruginosa exoenzyme S stimulates murine lymphocyte proliferation in vitro. Infect. Immun. 67: 4613-4619.
- Storey, D.G., E.E. Ujack, H.R. Rabin, I. Mitchell. 1998. Pseudomonas aeruginosa lasR transcription correlates with the transcription of lasA, lasBand toxA in the chronic lung infections associated with cystic fibrosis. Infect. Immun. 66(6): 2521-2528.
- Brumlik, M.J. and D.G. Storey. 1998. Post-transcriptional control of Pseudomonas aeruginosa LasB expression involves the 5' untranslated region of the mRNA. FEMS Microbiology Letters. 159(2): 233-239.
- Storey, D.G., E.E. Ujack, I. Mitchell and H.R. Rabin. 1997. Positive correlation of algD transcription to lasB and lasA transcription by populations of Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. Infect. Immun. 65(10): 4061-4067.
- Raivio, T.L., D. Hoffer, R.W. Prince, M.L. Vasil and D.G. Storey. 1996. Linker insertion scanning of regA, an lasA an activator of exotoxin A production in Pseudomonas aeruginosa. Mol. Microbiol. 22: 239-254.
- Raivio, T.L., E.E. Ujack, H.R. Rabin, D.G. Storey. 1994. An association between transcript levels of the Pseudomonas aeruginosa regA regB and tox A Genes in Sputa of Cystic Fibrosis Patients Infect. Immun. 62: 3506-3514.
- Frank, D.W. and D.G. Storey. 1994. Regulation of expression of Pseudomonas exotoxin A by iron. In Clark and Bavoil (eds), " Methods in Enzymology", 235: 502-517.
Are you the profile owner?
Login to edit.