Dr. Carrie Simone Shemanko
Positions
Professor
Member
Arnie Charbonneau Cancer Institute
Contact information
Phone number
Office: 403.220.3861
Lab: 403.210.8440
Location
Office: BI238C
Background
Educational Background
B.S. Genetic Biology, University of Alberta, 1988
Doctor of Philosophy Genetic Biology, University of Dundee, 1997
M.S. Biochemistry (Not Medicine), University of Alberta, 1993
Biography
Dr Carrie Shemanko established her own laboratory at the University of Calgary in 2002. She achieved her BSc and MSc (under the supervision of Dr Marek Michalak) at the University of Alberta, Canada, and obtained her PhD in Dundee, Scotland, UK, (under the supervision of Dr Birgitte Lane) with post-doctoral training in Freiburg and Frankfurt, Germany (under the supervision of Dr Bernd Groner). She has an interest in signal transduction and hormone driven signaling in mammary epithelial cells and in breast cancer. Her recent work on understanding the role of prolactin in the communication between metastatic breast cancer cells and the bone, has been published in the Journal of the National Cancer Institute and represents the collaborative effort between researchers in Canada, the USA, France and China. She is a founding member of the Breast Cancer to Bone (B2B) Metastasis Research Program (University of Calgary, Calgary, AB, Canada).
Research
Areas of Research
- Signal transduction in normal mammary gland development and cancer
The lab has two main, related focuses, the molecular controls involved in normal mammary gland (breast) development and how those molecular controls are disrupted and contribute to breast cancer and metastasis. My research integrates both developmental biology and cancer biology and trainees are exposed to a variety of novel techniques as well as integrated research approaches.
Participation in university strategic initiatives
Courses
| Course number | Course title | Semester |
|---|---|---|
| CMMB 519 | Advanced Cell Biology | Fall 2022 |
| BIOL 331 | Introduction to Cellular and Molecular Biology | Winter 2023 |
| CMMB 531 | Topics in Cellular Interactions | Winter 2023 |
Publications
More Information
Publications
- Garcia AE, Lai B, Gopinathan SG, Harris H, Shemanko CS, Jalilehvand F. Nuclear localization of dirhodium (II) complexes in breast cancer cells by X-ray fluorescence microscopy. Chemical Communications. 2019. DOI: 10.1039/C9CC00521H
- Karayazi Atici Ö, Urbanska A, Gopinathan SG, Boutillon F, Goffin V, Shemanko CS. ATM Is Required for the Prolactin-Induced HSP90-Mediated Increase in Cellular Viability and Clonogenic Growth After DNA Damage. Endocrinology. 2018 Feb 1;159(2):907-930. DOI: 10.1210/en.2017-00652
- Karayazi-Atici Ö, Urbanska A, Gopinathan SG, Boutillon F, Goffin V, Shemanko CS. ATM is required for the prolactin-induced HSP90-mediated increase in cellular viability and clonogenic growth after DNA damage. Endocrinology, en.2017-00652, https://doi.org/10.1210/en.2017-00652 Published:24 November 2017
- Shemanko CS, Cong YY, Forsyth A. What is Breast in the Bone? International Journal of Medical Science 2016 17(10): 1764 doi:10.3390/ijms17101764
- Shemanko, CS. Prolactin receptor in breast cancer: marker for metastatic risk. Invited Review Journal of Molecular Endocrinology 2016 57 (4): R153-R165 http://dx.doi.org/10.1530/JME-16-0150
- Ashley Sutherland; Amanda Forsyth; Yingying Cong; Laurel Grant; Tzu-Hua Juan; Jae K. Lee; Alexander Klimowicz; Stephanie K. Petrillo; Jinghui Hu; Angela Chan; Florence Boutillon; Vincent Goffin; Cay Egan; Patricia A. Tang; Li Cai; Don Morris; Anthony Magliocco; Carrie S. Shemanko. (2015) The Role of Prolactin in Bone Metastasis and Breast Cancer Cell-Mediated Osteoclast Differentiation. JNCI Journal of the National Cancer Institute 2016 108 (3): djv338. http://jnci.oxfordjournals.org/cgi/content/full/djv338?ijkey=KE2Msz1n5IvI6bm&keytype=ref
- Nigel T. Brockton, Stephanie J. Gill, Stephanie L. Laborge, Alexander H. G. Paterson, Linda S. Cook,
Hans J. Vogel, Carrie S. Shemanko, David A. Hanley, Anthony M. Magliocco and Christine M. Friedenreich (2015) The Breast Cancer to Bone (B2B) Metastases Research Program: a multi-disciplinary investigation of bone metastases from breast cancer. BMC Cancer (2015) 15:512
DOI 10.1186/s12885-015-1528-y - Radhakrishnan A, Raju R, Tuladhar N, Subbannayya T, Thomas JK,, Goel R, Telikicherla D, Palapetta SM, Mathur PP, Venkatesh DD, Urmila KK, Rahiman BA, Harsha HC, Prasad TSK, Shemanko C, Pandey A and Chatterjee A. Prolactin signaling pathway resource. J Cell Commun Signal. 2012 Aug;6(3):169-73. PMC link
- Perotti C, Karayazi Ö, Moffat S and Shemanko CS. Bone morphogenetic protein receptor-1a is required for mammary epithelial cell function. In Vitro Cell Dev Biol Anim. 2012 Jun;48(6):377-84 PMC link
- Shemanko CS. The response of breast cancer cells to chemotherapeutic agents and other anti-cancer treatments. In: Stem cells: organogenesis and cancer, Ed Shree Singh, Research Signpost/ Transworld Research Network Press. 2010:153-169, ISBN # is 978-81-7895-487-5
- Perotti C, Wiedl, T, Florin, L., Reuter, H., Moffat, S., Silbermann, M., Hahn, M., Angel, P, Shemanko CS. Characterization of mammary epithelial cell line HC11 using the NIA 15k gene array reveals potential regulators of the undifferentiated and differentiated phenotypes. Differentiation, 2009; 78:269-282 Pubmed abstract
- Perotti C, Liu R, Parusel C, Böcher N, Schultz J, Bork P, Pfitzner E, Groner B, Shemanko CS. Prolactin induces the expression of the heat shock protein 90a (HSP90a) gene and regulates apoptosis. Breast Cancer Research, 2008; 10(6):R94 Full text
- Brill B, Boecher, N, Groner. B, Shemanko CS. A sparing procedure to clear the mouse mammary fat pad of epithelial components for transplantation analysis. Lab Animal, 2008; 42:104-110 Pubmed abstract
- Shemanko CS. Mammary epithelial stem and progenitor cells and the prolactin pathway. Frontiers in Bioscience, 2008 13:3940-3950 Pubmed abstract
- Rugg EL, Horn HM, Smith FJ, Wilson NJ, Magee G, Shemanko CS, Tidman MJ, Lane EB. Epidermolysis bullosa simplex in Scotland is caused by a spectrum of keratin mutations. J Investig Dermatol, 2007; Mar;127(3):574-80 Full text
- Desrivieres S, Prinz T., Palomino-Laria N.C., Meyer, M., Boehm G., Schäfer J., Neumann T., Shemanko CS*, Groner B*, Comparative proteomic analysis of proliferating and functionally differentiated mammary epithelial cells. Molecular and Cellular Proteomics. 2003; 2:1039-1054 Full text
- McGrath, J. A., McMillan, J. R., Shemanko, C. S., Runswick, S. K., Leigh, I. M., Lane, E. B., Garrod, D. R., Eady, R. A.. (1997). Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome. Nat Genet 17, 240-4 Pubmed abstract
Book Chapters
- Shemanko CS. The response of breast cancer cells to chemotherapeutic agents and other anti-cancer treatments. In: Stem cells: organogenesis and cancer, Ed Shree Singh, Research Signpost/ Transworld Research Network Press. 2010:153-169, ISBN # is 978-81-7895-487-5
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