winston

Dr. Brent Warren Winston

Positions

Professor

Cumming School of Medicine, Department of Critical Care Medicine

Full Member

The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Immunology Research Group

Intensivist

Alberta Health Services

Contact information

Email

bwinston@ucalgary.ca

Web presence

Winston Website

Phone number

Office: +1 (403) 220-4341

Location

Office: HRIC4C64

Background

Educational Background

B.S. Animal Science, University of Calgary, 1980

Doctor of Medicine Medicine, University of Alberta, 1984

Courses

Course number Course title Semester
MDSC 62303 LEC 01 01 Respiratory Science: Basic 2020
MDSC 62303 TUT 01 T01 Respiratory Science: Basic 2020

Projects

System Biology Approach to Developing Bedside Early Detection Formula with COVID-19 ARDS Patients

The Lung Association of Alberta - Co PI's Dr. Chel Hee Lee and Dr. Brent W. Winston, 2022-2023, $30,000

Using Matabolomics for Early Detection and Prognosis of Patients with COVID-19 ARDS

VPR Catalyst Grant, University of Calgary, PI Dr. Brent W. Winston, 2021-2022, $13,500

Analyzing and Validating ARDS Metabolimics using Robust Statistical Methods

The Lung Association of Alberta, PI: Dr. Brent W. Winston, 2021-2021, $30,000

Using a Metabolomics Approach for Severe TBI Prognosis,

URGC PI Dr. Brent Winston, 2020-2021, $15,000

The Lung Association of Alberta Relative Folate Deficiency Contributes to ARDS: A Validation Stud

The Lung Association of Alberta PI Dr. Brent W. Winston, 2019-2021, $30,000

Validation of metabolomics-defined ARDS Endotypes

The Lung Association of Alberta, PI Dr. Brent W. Winston, 2017-2019, $30,000

Differentiating ALI and ARDS from Ventilated ICU Controls Using Serum Metabolomics

Canadian Intensive Care Foundation, PI Dr. Brent W. Winston; 2013-2014, $28,500

Awards

  • The Michael Ward Award from the Canadian Critical Care Forum for the Best Basic or Translational Science Study, 2021
  • Research Snapshot Award at the SCCM Annual Meeting, 2017
  • Professional Development Grant/Award to Support Training - "Learning how to apply LC-MS to critical care patients" UCD, Davis California, 2015
  • Best Basic Science Poster (with Beata Mickiewics) at the Critical Care Canada Forum, Toronto, 2013
  • Association of Alberta and NWT Lifetime Membership for Rendering Extraordinary Service in Pursuit of the Objectives of the Association, 2013
  • Canadian Lung Association Lifetime Membership for contributions made to the Lung Association, 2012
  • AHFMR Scholar Award (Salary Support), 2004
  • Toronto Critical Care Conference - Best Adult Poster, 2003
  • Toronto Critical Care Conference - Best Adult Poster, 2002
  • AHFMR Senior Clinical Investigator Award, 1999
  • The Canadian Society of Clinical Investigation's 1998 Joe Doupe Young Investigator's Award, 2021
  • Medical Research Council of Canada Scholarship, 1991
  • Medical Research Council of Canada Research Fellowship, 1991
  • The Will Rogers Institute Pulmonary Research Fellowship, 1989

Publications

PubMed

More Information

Research Activities

The research focus in my laboratory has been in three areas:

1)  Metabolomics in human diseases in Critical Care. We continue to study serum metabolomics in sepsis, lung injury and head injury.

2)  Gene regulation in sepsis.  We have examined gene regulation in macrophages in sepsis with a focus on the alternative complement cascade Factor B and have examined IGF-I gene regulation in lungs with an interest in acute and chronic lung fibroproliferation.

3)  Clinical/Translational studies on sepsis. We have participated in a number of sepsis clinical studies.  To this end, I have created a Critical Care Tissue bank to conduct translational research on clinically important problems in the ICU and have also created a wet lab within the ICU to manage samples.

My laboratory is particularly interested in conducting translational research on clinically relevant Critical Care and Pulmonary disease processes.

Research Areas: 

Cell Signalling and Structure