Braedon McDonald

Braedon McDonald

MD, PhD, FRCPC

Positions

Associate Professor

Cumming School of Medicine, Department of Critical Care Medicine

Intensive Care Specialist

Foothills Medical Centre, Alberta Health Services

Full Member

The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases

Calvin, Phoebe, and Joan Snyder Chair in Critical Care Research

Cumming School of Medicine

Director of Research and Innovation

Cumming School of Medicine, Department of Critical Care Medicine

Contact information

Phone number

Office: 403.220.6885
Lab: 403.220.4423

Location

Lab: HSC 1718

Background

Credentials

FRCPC -Critical Care Medicine, University of Calgary, 2018

FRCPC -Internal Medicine, University of British Columbia, 2016

Educational Background

Postdoctoral Fellowship - Microbiome and Immunity -, International Microbiome Centre, University of Calgary, 2020

PhD - Immunology, University of Calgary, 2013

MD University of Calgary, 2013

BSc - Microbiology and Immunology, McGill University, 2007

Biography

Dr. Braedon McDonald is an Associate Professor in the Department of Critical Care Medicine and Department of Medicine in the Cumming School of Medicine. Dr. McDonald holds the Calvin, Phoebe, and Joan Snyder Chair in Critical Care Research, and is Director of Research and Innovation for the Department of Critical Care Medicine. Dr. McDonald is a clinician-scientist in the Snyder Institute for Chronic Diseases and International Microbiome Centre, where he leads a translational and basic science research program on microbiome-immune interactions in infection and critical illness. Dr. McDonald’s clinical practice focuses on multi-systems intensive care, and he is an attending intensivist in the ICU at FMC and SHC.

Research

Participation in university strategic initiatives

Projects

Immunity, inflammation, and the microbiome in critical illness

1.  Microbiology and immunology of infections and sepsis in the ICU.

  • Gut microbiota dysbiosis in the pathogenesis of nosocomial infections and organ dysfunction in the ICU.
  • Multi-dimensional profiling of microbiota-immune interactions in ICU patients.
  • Host-microbe interactions and immune dysfunction in critical illness.

2.  Microbiota-immune interactions in the regulation of host defense against infections and sepsis.

  • Intravital imaging of host-microbe interactions in vivo.
  • Germ-free and gnotobiotic models of ICU dysbiosis.
  • Cellular and molecular mechanisms of microbiota-immune interactions during sepsis and critical illness.

3.  Translational research into precision therapeutics for the prevention and treatment of infections and sepsis in the ICU.

  • Development of precision microbiota-editing strategies to modulate microbiota-immune mutualism.
  • Immunotherapy for the treatment of infections and sepsis.

Publications

More Information

Katrina Yu
Lab Manager
ianling.yu@ucalgary.ca

Matthew Stephens, PhD
Research Associate
matthew.stephens@ucalgary.ca

Niki Cho, PhD
Postdoctoral Fellow
nacho@ucalgary.ca

Colin MacKenzie, PhD 
Postdoctoral Fellow
colin.mackenzie1@ucalgary.ca

Jared Schlechte
PhD candidate
jared.schlechte@ucalgary.ca

Ayesha Wijesinghe
PhD student
ayesha.wijesinghe@ucalgary.ca

Kathryn Strayer
PhD student
kathryn.strayer1@ucalgary.ca

Anthony Machado
CMMB Honours Project student
anthony.machado@ucalgary.ca

Jaida Fuder
Undergraduate summer student
Jaida.fuder@ucalgary.ca

Chelsea Davidson
Email: chelsea.davidson@albertahealthservices.ca