Braedon McDonald

Braedon McDonald



Assistant Professor

Cumming School of Medicine, Department of Critical Care Medicine

Intensive Care Specialist

Foothills Medical Centre, Alberta Health Services

Full Member

The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases

Full Member

Inflammation Research Network

Contact information

Phone number

Office: 403.220.6885
Lab: 403.220.4423


Lab: HSC 1718



FRCPC -Critical Care Medicine, University of Calgary, 2018

FRCPC -Internal Medicine, University of British Columbia, 2016

Educational Background

Postdoctoral Fellowship - Microbiome and Immunity -, International Microbiome Centre, University of Calgary, 2020

PhD - Immunology, University of Calgary, 2013

MD University of Calgary, 2013

BSc - Microbiology and Immunology, McGill University, 2007


Dr. Braedon McDonald is an Assistant Professor in the Department of Critical Care Medicine and Department of Medicine in the Cumming School of Medicine.  Originally from Crossfield, AB, Dr. McDonald trained in microbiology and immunology at McGill University in Montreal, followed by MD as well as PhD training in immunology at the University of Calgary.  He completed Internal Medicine residency at the University of British Columbia, followed by a fellowship in adult Critical Care Medicine at the Cumming School of Medicine. Dr. McDonald completed a CIHR- and AIHS-funded postdoctoral fellowship in microbiome research at the University of Calgary’s International Microbiome Centre.  Dr. McDonald is a clinician-scientist in the Snyder Institute for Chronic Diseases and International Microbiome Centre, where he leads a translational and basic science research program on microbiome-immune interactions in infection and critical illness. Dr. McDonald’s clinical practice focuses on multi-systems intensive care, and he is an attending intensivist in the ICU at FMC, RGH, and SHC.


Participation in university strategic initiatives


Immunity, inflammation, and the microbiome in critical illness

1.  Microbiology and immunology of infections and sepsis in the ICU.

  • Gut microbiota dysbiosis in the pathogenesis of nosocomial infections and organ dysfunction in the ICU.
  • Multi-dimensional profiling of microbiota-immune interactions in ICU patients.
  • Host-microbe interactions and immune dysfunction in critical illness.

2.  Microbiota-immune interactions in the regulation of host defense against infections and sepsis.

  • Intravital imaging of host-microbe interactions in vivo.
  • Germ-free and gnotobiotic models of ICU dysbiosis.
  • Cellular and molecular mechanisms of microbiota-immune interactions during sepsis and critical illness.

3.  Translational research into precision therapeutics for the prevention and treatment of infections and sepsis in the ICU.

  • Development of precision microbiota-editing strategies to modulate microbiota-immune mutualism.
  • Immunotherapy for the treatment of infections and sepsis.


More Information

Kathryn Strayer
MSc Student

Simarpreet Kaur
MSc Student

Diana Changirwa
MD-MSc Student

Breenna Dobson
MSc Student

Jared Schlechte
PhD Candidate

Ayesha Wijesinghe
PhD Student

Niki Cho
Postdoctoral Fellow

Katrina Yu
Lab Manager


Angie Lamb
HSC 1875
Phone: 403.210.8635