Dr. Augusto Faria Andrade
Positions
Assistant Professor
Cumming School of Medicine, Department of Biochemistry and Molecular Biology
Member
Arnie Charbonneau Cancer Institute
Contact information
Web presence
Preferred method of communication
Administrative Assistant
Patty Nielsen
Email: nielsenp@ucalgary.ca
Office: 403.210.6187
Background
Biography
Dr. Augusto Andrade is a cancer biologist specializing in pediatric neuro-oncology. He obtained his PhD from the University of São Paulo in the laboratory of Professor Luiz Gonzaga Tone. He completed his research training in the laboratory of Dr. Nada Jabado at McGill University, where he investigated the tumor microenvironment of pediatric gliomas, with a focus on immune cells. His work has contributed to understanding how the interplay between chromatin state and immune cells shapes tumor progression and therapeutic response. Dr. Andrade established his research laboratory at the University of Calgary in the Department of Biochemistry & Molecular Biology, in the Cumming School of Medicine.
Research
Areas of Research
- The interplay between chromatin state and the microenvironment in pediatric brain tumors
Our research focuses on understanding the brain microenvironment in both cancer and neurodevelopmental contexts, with a particular emphasis on pediatric gliomas and neurodegeneration. We integrate cutting-edge technologies, including single-cell and spatial transcriptomics, imaging mass cytometry, and in vivo experimental models, aiming to explore how epigenetics shapes disease progression. A key area of investigation is the interplay between immune infiltration and chromatin state in pediatric brain tumors. Given the challenges of treating these aggressive cancers, we aim to uncover how epigenetic dysregulation influences immune cell behavior and contributes to tumor formation and therapy resistance. Using human tumor samples, transgenic mouse models, and patient-derived glioma cells, we employ transcriptomic and epigenomic approaches to deeply characterize immune populations and their epigenetic landscapes. Our work will provide critical insights into the molecular mechanisms driving pediatric gliomas and pave the way for novel therapeutic strategies.
Publications
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