Ann Clarke

Dr. Ann Clarke




Cumming School of Medicine, Department of Medicine


Cumming School of Medicine, Department of Community Health Sciences

Full Member

McCaig Institute for Bone and Joint Health

Full Member

O'Brien Institute for Public Health

Child Health & Wellness Researcher

Alberta Children's Hospital Research Institute

The Arthritis Society Research Chair in Rhematology/Rheumatic Disease

University of Calgary


University of Calgary Lupus Centre of Excellence

Contact information

Phone number

Office: +1 (403) 220-8737

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Educational Background

Doctor of Medicine Medicine, Memorial University, 1984

M.S. Health Research & Policy, Stanford University, 1993


I am a Professor in the Division of Rheumatology, Department of Medicine, University of Calgary and hold the Arthritis Society Chair in Rheumatic Diseases. I am an established investigator in the epidemiology, economics, and outcomes of rheumatic diseases, particularly systemic lupus erythematosus (SLE). Between 1997 and 2013, I was Co-Director of the McGill University Health Centre Lupus Clinic, one of the largest such clinics in North America, and in 2013, I instituted and am the current Director of the University of Calgary Lupus Centre of Excellence. I am the immediate past Chair of the Systemic Lupus International Collaborating Clinics (SLICC), a group of world-renowned lupus investigators. As such, I have contributed to the development of both the SLICC and European League Against Rheumatism/ American College of Rheumatology (EULAR/ACR) Classification Criteria for SLE, which are more clinically relevant than the previous criteria, and are now the accepted standard for identifying patients for trials and observational research. We have produced standardized measures for lupus disease activity and damage that are fundamental to all lupus research and conducted pivotal longitudinal cohort studies on cardiovascular, neuropsychiatric, renal, and economic outcomes. I have contributed to an international task force (Definition of Remission in SLE: DORIS) that is re-defining optimal management strategies in SLE. Through numerous national and international collaborations, my research team has assembled the largest-ever international SLE cohort and provided the first definitive evidence on the association between SLE and malignancy. I have received support from numerous Canadian and American peer-reviewed granting agencies and charitable organizations, have published over 400 manuscripts, and am very engaged in the training of the next generation of lupus clinicians and investigators. 


Areas of Research

Systemic Lupus Erythematosus (SLE), Epidemiology, Health Economics, Antiphospholipid Antibody Syndrome (APS)

Participation in university strategic initiatives


Calgary Lupus Centre of Excellence

Dr. Clarke is also the Director of the University of Calgary Lupus Centre of Excellence, which offers the highest possible standard of care, informed by research, to patients with SLE in a multidisciplinary care environment. Through research and clinical care activities, rheumatologists and immunologists collaborate with hematologists, nephrologists, maternal fetal medicine specialists, and dermatologists to design patient-centred treatment strategies which effectively control lupus disease activity while minimizing side effects.  The team has particular expertise in antiphospholipid antibody syndrome, lupus nephritis, and pregnancy.

World-renowned researchers at the Lupus Centre of Excellence are dedicated to advancing understanding of the causes, diagnosis, and treatment of SLE and translating these discoveries into practices and policies that provide a healthier future for those with lupus. The Centre also participates in clinical trials, providing patients with access to some of the newest therapies. 

The Lupus Centre of Excellence is committed to providing specialized clinical and research training for the next generation of physicians and partnering with patients to increase awareness and find a cure.