Angela Chan
Positions
Adjunct Research Assistant Professor
Cumming School of Medicine, Department of Oncology
Member
Arnie Charbonneau Cancer Institute
Contact information
Phone number
Office: 587.231.4835
Location
Office: Arthur ChildYC073233
Preferred method of communication
Background
Credentials
MLT, 2010
Educational Background
BSc University of Calgary, 2005
MSc University of Calgary, 2008
Biography
Ms. Angela Chan is a Research Scientist and Scientific & Operations Lead of the Functional Tissue Imaging Unit at the Cancer Translational Research Core, Cancer Care Alberta, and an Adjunct Research Assistant Professor in the Department of Oncology at the Cumming School of Medicine, University of Calgary. She received her Bachelor of Science in Biochemistry, with minors in Applied Mathematics and Chemistry, and Master of Science in Biochemistry and Molecular Biology from the University of Calgary.
Angela began her career as a research associate at a local biotech company where she developed skills in pharmaceutical ingredient purifications. In 2009, she returned to the public sector and joined Genetic Laboratory Services as a Medical Laboratory Technologist, where she specialized in clinical molecular testing and assay development. She later served as a Research Associate in the Translational Laboratories and Biospecimen Processing Laboratory, leading high-throughput biobanking and biomarker discovery projects. Since 2017, she has led the scientific direction of the Functional Tissue Imaging Unit, focusing on biomarker assay development, multiplex immunofluorescence, digital pathology, and machine learning applications in oncology. She played a key role in achieving clinical accreditation for novel diagnostics, including automated Ki67 digital analysis for breast cancer prognosis.
Her research focuses on precision oncology, biomarker discovery, clinical implementation, immune profiling, and tumor microenvironment analysis across multiple cancer types. She is an active member of several national and international consortia, including the Terry Fox Research Institute’s Marathon of Hope Cancer Centres Network, where she chairs the validation study of the immune profiling validation working group.
Research
Areas of Research
- Cancer biomarker translation and implementation
- Precision oncology
- Digital pathology
Angela Chan’s research mainly focuses on two areas. First, advance precision oncology through the development and validation of biomarker assays that improve cancer diagnostics, prognosis, and treatment selection. She has led the design and accreditation of innovative lab-developed tests, including automated Ki67 digital analysis to predict breast cancer risk of recurrence, and used as a complementary diagnostic tool with targeted therapy of CDK4/6 inhibitors. Secondly, her interest is in advancing the understanding of tumor biology, the immune microenvironment, and predictive biomarkers in breast, cervical, lung, anal, and other cancers. She focuses on developing and standardizing multiplex immune profiling assays to gain a deeper understanding of the tumor microenvironment. Her expertise spans immunohistochemistry, multiplex immunofluorescence, digital pathology, and machine learning applications in tissue imaging. Her research integrates translational science with clinical practice, encompassing retrospective and prospective studies, clinical trials, and investigator-initiated trials.
Publications
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