Alex Lohman

Dr. Alexander Lohman

PhD
Pronouns: He/Him

Positions

Assistant Professor

Cumming School of Medicine, Department of Cell Biology and Anatomy

Full Member

Hotchkiss Brain Institute

Child Health & Wellness Researcher

Alberta Children's Hospital Research Institute

Contact information

Web presence

Phone number

Office: 403.220.2898

Location

Office: HMRB 159
Lab: HMRB161

Background

Educational Background

B.S. Biochemistry, University of Missouri-Columbia, 2010

Doctor of Philosophy Molecular Physiology and Biological Physics, University of Virginia, 2014

Postdoctoral Fellow - Thompson Lab Neuroscience, University of Calgary, 2018

Research

Areas of Research

Brain Injury
Inflammation
Molecular Mechanisms
Stroke
Tissue Regeneration
Activities

My research program centers on deciphering neuroinflammatory dynamics following single and repetitive brain injuries. We use a multidisciplinary approach spanning neuroscience, immunology, molecular biology and biochemistry to understand key driving forces that determine whether brain inflammation is good or bad at acute and chronic time points following injury. Our initial focus is on repetitive, mild traumatic brain injury (concussion) in adolescence using a novel lateral impact model for mild TBI which recapitulates the clinical pathology and symptomology. We employ awake animals, in vivo multiphoton imaging combined with flow cytometric immunophenotyping, single cell RNA sequencing and inflammatory cytokine panels to understand central axes regulating phenotypic transitions between beneficial and harmful neuroinflammation. Our program is significantly expanding the research field in this realm by developing newly-engineered, optically-controlled genetically encoded proteins and biosensors to specifically interogate molecular signaling pathways influencing acute and chronic neuroinflammatory pathologies.

Participation in university strategic initiatives

Courses

Course number Course title Semester
MDSC 61902 LAB 01 B01 Sys Neuroscience & Neuropath 2021
MDSC 61902 LEC 01 01 Sys Neuroscience & Neuropath 2021