Dr. Alexander Lohman, PhD
Cumming School of Medicine, Department of Cell Biology and Anatomy
Hotchkiss Brain Institute
Child Health & Wellness Researcher
Alberta Children's Hospital Research Institute
B.S. Biochemistry, University of Missouri-Columbia, 2010
Doctor of Philosophy Molecular Physiology and Biological Physics, University of Virginia, 2014
Postdoctoral Fellow - Thompson Lab Neuroscience, University of Calgary, 2018
Areas of Research
My research program centers on deciphering neuroinflammatory dynamics following single and repetitive brain injuries. We use a multidisciplinary approach spanning neuroscience, immunology, molecular biology and biochemistry to understand key driving forces that determine whether brain inflammation is good or bad at acute and chronic time points following injury. Our initial focus is on repetitive, mild traumatic brain injury (concussion) in adolescence using a novel lateral impact model for mild TBI which recapitulates the clinical pathology and symptomology. We employ awake animals, in vivo multiphoton imaging combined with flow cytometric immunophenotyping, single cell RNA sequencing and inflammatory cytokine panels to understand central axes regulating phenotypic transitions between beneficial and harmful neuroinflammation. Our program is significantly expanding the research field in this realm by developing newly-engineered, optically-controlled genetically encoded proteins and biosensors to specifically interogate molecular signaling pathways influencing acute and chronic neuroinflammatory pathologies.
Participation in university strategic initiatives
|Course number||Course title||Semester|
|MDSC 61902 LAB 01 B01||Sys Neuroscience & Neuropath||2021|
|MDSC 61902 LEC 01 01||Sys Neuroscience & Neuropath||2021|
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