Headshot

Adriana Zardini Buzatto

MSc, PhD
Pronouns: she/her/hers

Positions

Full Member

Hotchkiss Brain Institute, Mathison Centre for Mental Health Research and Education

Contact information

Web presence

Location

Office: BI447

I'm looking for...

Research partners

I am looking for collaborations to study the relationship between lipids and neurological diseases. Please contact me for more information.

Background

Educational Background

PhD Chemistry, University of Alberta,

MSc Chemistry, Universidade Estadual de Campinas, Brazil,

BSc Chemistry, Universidade Estadual de Campinas, Brazil,

Biography

I began my research journey as an undergraduate student in Brazil in 2008. After completing my master’s degree in targeted metabolomics with Dr. Ana Valeria Colnaghi Simionato, I enrolled in the Ph.D. program at the University of Alberta, Canada, under the supervision of Dr. Liang Li. My research focused on lipidomics of biological samples using nanoLC and UHPLC-MS, including lipid biomarkers of cystic fibrosis, Parkinson's, dementia, Alzheimer's, and other human conditions. After graduating in 2020, I joined the Nova Medical Testing and TMIC research teams as a scientist, where I led a team that applied the methodologies I developed for service work and collaborative research focused on lipids. I joined the Department of Biological Sciences at the University of Calgary in July/2023 as an Assistant Professor. My emerging program focuses on the role of lipid species in human metabolism and diseases, with particular emphasis on the role of lipids in neurodegeneration, intercellular communication through extracellular vesicles, and the human microbiome. I aim to establish a robust lipidomics core that operates in synergy with the Calgary Metabolomics Research Facility (CMRF) and the Alberta Centre for Advanced Diagnosis (ACAD).

Research

Areas of Research

Lipidomics (analytical methods using chromatography and mass spectrometry, database creation, software development, data sciences)

My primary research focus is on untargeted lipidomics using LC-MS (liquid chromatography coupled with high-resolution mass spectrometry). Lipidomics is the quantitative and qualitative investigation of lipids and their relationship with biochemical pathways, diseases, and physiological reactions. My objective is to analyze a wide range of lipids in highly complex biological samples such as cells, extracellular vesicles, serum, tissue, and cerebrospinal fluid.

Lipids involved in neurodegeneration and neurological diseases (ALS, Parkinson's, Alzheimer's, dementia, and others)
Lipidomics of extracellular vesicles and their correlation with intercellular communications and pathological processes
Lipidomics of the human microbiome - defining the lipid composition of human bacteria at a detailed level

Participation in university strategic initiatives

Courses

Course number Course title Semester
BCEM 555 Biomembranes Winter 2024

Publications